2022年6月9日,备受血液学领域瞩目的第27届欧洲血液学协会(EHA)年会将如期而至。本次EHA首次采取了线上联合线下综合会议模式。当地时间5月12日16:00,大会摘要公布。小编第一时间检索出21篇中国专家在本届EHA的口头发言,并简要整理,以供大家参考。
(按摘要号排列先后)
陆道培医院 陆佩华教授团队
摘要号S110: 一种新型且成功的CD7基因敲除CAR-T细胞治疗复发或难治性T细胞血液恶性肿瘤
原标题:A NOVEL AND SUCCESSFUL CD7 GENE KNOCKOUT CAR-T CELL THERAPY FOR RELAPSED OR REFRACTORY T-CELL HEMATOLOGIC MALIGNANCIES
作者:Junfang Yang,Jingjing Li, Xian Zhang, Liyuan Qiu, Peihua Lu
发言人:Peihua Lu
摘要号S213: 人源化与鼠源化CD19和CD22 CAR-T细胞鸡尾酒疗法治疗难治性/复发性B细胞淋巴瘤的疗效和安全性
原标题:EFFICACY AND SAFETY OF HUMANIZED VERSUS MURINIZED CD19 AND CD22 CAR-T CELL COCKTAIL THERAPY FOR REFRACTORY/RELAPSED B-CELL LYMPHOMA
作者:Lefu Huang, Jingjing Li,Junfang Yang, Xian Zhang, Min Zhang, Jiujiang He, Gailing Zhang, Yunchao Su, Wenqian Li, Hui Wang, Peihua Lu
发言人:Peihua Lu
中国医学科学院血液病医院 王建祥教授团队
摘要号S121: 具有新型抗原结合域的CD123-CD33复合CAR-T细胞为急性髓系白血病的治疗提供了一种新的方法
原标题:CD123-CD33 COMPOUND CAR-T CELLS WITH NOVEL ANTIGEN BINDING DOMAINS PROVIDE A NEW HOPE FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA
作者:Zhenzhen Wang, Yang LU, Shaowei Qiu, Min Wang, Dongsheng Xiong, Jianxiang Wang
发言人:Zhenzhen Wang
北京大学人民医院 黄晓军教授团队
摘要号S124:骨形态发生蛋白2因子触发的急性髓系白血病中ΓΔT细胞免疫抑制效应
原标题:BONE MORPHOGENETIC PROTEIN 2 TRIGGERS OFF AN IMMUNOSUPPRESSIVE EFFECT OF ΓΔ T CELLS IN ACUTE MYELOID LEUKEMIA
作者:huang Liang, Tianhui Dong, Keli Yue, Haitao Gao, Ning Wu, Ruoyang Liu, Jiangying Liu, Xiao-Jun Huang
发言人:Shuang Liang
摘要号S290: ATRA可纠正ITP原代血小板形成中HIF-1α/S1P AXIS介导的细胞骨骼重组缺陷
原标题:ATRA CAN CORRECT DEFECTIVE HIF-1Α/S1P AXIS-MEDIATED CYTOSKELETAL REORGANIZATION IN PROPLATELET FORMATION OF ITP
作者:Qiu-Sha Huang, Jing Xue, Feng-Qi Liu, Qi Chen, Gao-Chao Zhang, Xue-Yan Sun, Chen-Cong Wang, Li-Ping Yang, Yue-Ying Li, Qian-Fei Wang, Jun Peng, Ming Hou, Xiao-Jun Huang, Xiao-Hui Zhang
发言人:Qiu-Sha Huang
摘要号S231: 糖皮质激素和糖酵解抑制剂协同治疗急性移植物抗宿主病
原标题:GLUCOCORTICOID AND GLYCOLYSIS INHIBITORS COOPERATIVELY ABROGATE ACUTE GRAFT-VERSUS-HOST DISEASE
作者:qi wen,zhengli xu, yu wang, meng lv, yang song, zhongshi lv, tong xing, lanping xu, xiaohui zhang, xiaojun huang, yuan kong
发言人:Zhengli Xu
摘要号S234: 与原代NK细胞相比,临床级MBIL21/4-1BBL扩增NK细胞在抗HCMV感染方面更具优势
原标题:CLINICAL-GRADE MBIL21/4-1BBL EXPANDED NK CELLS EXHIBIT STRONGER COMPETENCE COMPARED WITH PRIMARY NK CELLS AGAINST HCMV INFECTION
作者:Qian-Nan Shang, Xing-Xing Yu, Zheng-Li Xu, Ting-Ting Han, Juan Xie, Ze-Ying Fan, Ming Zhao, Xun-Hong Cao, Xue-Fei Liu, Yu-Hong Chen, Meng Lv, Yu-Qian Sun, Ying-Jun Chang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiang-Yu Zhao,Xiao-Jun Huang
发言人:Qian-Nan Shang
摘要号S239: APLASTIC贫血中单倍型和同型同胞供者HSCT之间的长期结局相当:一项基于国家登记的研究
原标题:COMPARABLE LONG-TERM OUTCOMES BETWEEN UPFRONT HAPLOIDENTICAL AND IDENTICAL SIBLING DONOR HSCT IN APLASTIC ANEMIA: A NATIONAL REGISTRY-BASED STUDY
作者:zhengli xu, lanping xu, depei wu, shunqing wang, xi zhang, rui xi, sujun gao, linghui xia, jianmin yang , ming jiang, xin wang, qifa liu, jia chen, ming zhou, xiaojun huang
发言人:zhengli xu
台湾大学医学团队
这摘要号S131: 原发性急性髓系白血病患者中继发AML突变的临床意义
原标题:CLINICAL IMPLICATIONS OF SECONDARY-AML TYPE MUTATIONS IN PATIENTS WITH DE NOVO ACUTE MYELOID LEUKEMIA
作者:Kuojui Sun, Cheng-Hong Tsai, Min-Yen Lo, Mei-Hsuan Tseng, Yuan-Yeh Kuo, Ming-Chih Liu, Chien-Chin Lin, Chieh-Lung Cheng, Shang-Ju Wu, Chien-Yuan Chen, Bor-Sheng Ko, Ming Yao, Wen-Chien Chou, Hsin-An Hou, Hwei-Fang Tien
发言人:Kuojui Sun
陆军军医大学第二附属医院 张曦教授团队
摘要号S133: 现成CD33 CAR-NK细胞治疗复发性/难治性AML的首次人体I期试验
原标题:OFF-THE-SHELF CD33 CAR-NK CELL THERAPY FOR RELAPSE/REFRACTORY AML: FIRST-IN-HUMAN, PHASE I TRIAL
作者:Ruihao Huang, Qin Wen, Xiaoqi Wang, Hongju Yan, Yingying Ma, Maihong Wang, Xiao Han, Li Gao, Lei Gao, Cheng Zhang, Xi Zhang
发言人:Ruihao Huang
摘要号S242: 单次造血干细胞移植后早期输注MSCS预防GVHD
原标题:EARLY INFUSION OF MSCS IN THE PROPHYLAXIS OF GVHD AFTER HAPLO-HEMATOPOIETIC STEM-CELL TRANSPLANTATION
作者:Ruihao Huang,Ting Chen, Sanbing Wang,Jishi Wang, Yi Su, Jing Liu, Qin Wen, Peiyan Kong, Cheng Zhang, Lei Gao, Li Gao, Xi Zhang
发言人:Ruihao Huang
北京协和医院 李剑教授团队
摘要号S172: AL淀粉样变性中与淀粉样蛋白生成和venetoclax敏感性相关的浆细胞功能亚组
原标题:FUNCTIONAL SUBSETS OF PLASMA CELLS ASSOCIATED WITH AMYLOID PRODUCTION ANDVENETOCLAX SENSITIVITY IN AL AMYLOIDOSIS
作者:Xuezhu Wang, Hongxiao Han , Jian Sun, Qi Wang, Xue-min Gao, Kai-ni Shen, Lu Zhang, Yushan Zhao, Xin-xin Cao,Minping Qian, Yang Chen, Jian Li
发言人:Xuezhu Wang
上海长征医院 杜鹃教授团队
摘要号S186:在复发性/难治性多发性骨髓瘤(RRMM)患者中进行的BCMA/CD19双靶向快速CAR-T GC012F多中心首次人体研究的更新结果
原标题:UPDATED RESULTS OF A MULTICENTER FIRST-IN-HUMAN STUDY OF BCMA/CD19 DUAL-TARGETING FAST CAR-T GC012F FOR PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM)
作者:Juan Du, Hua Jiang, Baoxia Dong, Li Gao, Li Liu, Jian Ge, Aili He, Lu Li, Jing Lu, Xiequn Chen,Martina Sersch, Hua Zhang, Lianjun Shen, Jia Liu, Weijun Fu
发言人:Juan Du
华中科技大学同济医学院附属同济医院 周剑峰教授团队和中国医学科学院北京协和医学院 邱录贵教授团队
摘要号S187: CT103A(完全人BCMA靶向CAR T细胞)治疗复发性/难治性多发性骨髓瘤的安全性和疗效的i/ii期更新数据
原标题:UPDATED PHASE 1/2 DATA OF SAFETY AND EFFICACY OF CT103A, FULLY HUMAN BCMA-DIRECTED CAR T CELLS, IN RELAPSED/REFRACTORY MULTIPLE MYELOMA
作者:Chunrui Li, Di Wang, Yongping Song, Jianyong Li, He Huang, Bing Chen, Jing Liu, Kai Hu, Hanyun Ren, Xi Zhang, Zhenyu Li, Dehui Zou, Qingsong Yin, Lijuan Chen, Yongxian Hu, Yong Xu, Qian Cheng, Yuelu Guo, Yujun Dong, Li Gao, Shan Chen, Aining Xu, Songbai Cai, Ming Wu, Jingjing Guo, Zheng Yao, Wen Wang, Jue Wang, Liting Chen,Jianfeng Zhou, Lugui Qiu
发言人::Chunrui Li
中国医学科学院血液病医院团队
摘要号S190: 骨髓增生性肿瘤中通过EGR1-TNFA轴介导的炎症和纤维细胞生成的ASXL1突变加速骨髓纤维化
原标题:ASXL1 MUTATIONS ACCELERATE BONE MARROW FIBROSIS VIA EGR1-TNFA AXIS MEDIATED INFLAMMATION AND FIBROCYTE GENERATION IN MYELOPROLIFERATIVE NEOPLASMS
作者:Zhongxun Shi , Jinqin Liu, Yingying Zhao, Lin Yang, Yanan Cai, Peihong Zhang, Zefeng Xu, Tiejun Qin, Shiqiang Qu, Lijuan Pan, Junying Wu, Xin Yan, Zexing Li, Wenjun Zhang, Yiru Yan, Huijun Huang
发言人:Zhongxun Shi
北京大学肿瘤医院 朱军教授
摘要号S218:选择性JAK1抑制剂格列替尼治疗难治性或复发性外周T细胞淋巴瘤的I/II期研究
原标题:A PHASE I/II STUDY OF GOLIDOCITINIB, A SELECTIVE JAK1 INHIBITOR, IN REFRACTORY OR RELAPSED PERIPHERAL T CELL LYMPHOMA
作者:Won-Seog Kim, Dok-Hyun Yoon, Yuqin Song, Haiyan Yang, Junning Cao, Dongmei Ji, Youngil Koh, Hongmei Jing, Hyeon-Seok Eom, Jae-Yong Kwak, Won-Sik Lee, Jong-Seok Lee, Ho-Jin Shin, Jie Jin, Mei Wang, Jason Li, Xubin Huang, Xueyuan Deng, Zhenfan Yang, Jun Zhu
发言人:Won-Seog Kim
北京协和医院 周道斌教授团队
原标题:PRELIMINARY RESULTS OF A PHASE II STUDY OF ORELABRUTINIB IN COMBINATION WITH ANTI-PD-1 MONOCLONAL ANTIBODY IN REFRACTORY OR RELAPSED PRIMARY CNS LYMPHOMA
作者: Yan Zhang, Wei Wang, Danqing Zhao, Wei Zhang, Daobin Zhou
发言人:Yan Zhang
南京医科大学第一附属医院 李建勇教授团队
摘要号S229:用单细胞RNA序列和MASS细胞计数法对AITL进展过程中肿瘤微环境重塑的表征
原标题:CHARACTERISATION OF TUMOR MICROENVIROMENT REMODELLING IN THE PROGRESSION OF AITL WITH SINGLE-CELL RNA SEQUENCING AND IMAGING MASS CYTOMETRY
作者:Hui Jin, Xueying Lu, Lei Fan, Lei Cao, Wei Zhang, Jianyong Li, Zijuan Wu
发言人:Hui Jin
高博医学(血液病)北京研究中心团队
原标题:CD7 CHIMERIC ANTIGEN RECEPTOR T CELLS BRIDGING TO ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IMPROVED DISEASE-FREE SURVIVAL IN REFRACTORY/RELAPSED T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
作者:Zhihui Li, Xianxuan Wang, Xiaopei Wen, Teng Xu, Yanzhi Song, Tong Wu
发言人:Zhihui Li
浙江大学医学院附属第一医院 黄河教授团队
摘要号S263: GPRC5D CAR-T细胞(ORICAR-017)治疗复发性/难治性多发性骨髓瘤(POLARIS)患者的I期、开放性、单组研究
原标题:PHASE I OPEN-LABEL SINGLE ARM STUDY OF GPRC5D CAR-T CELLS (ORICAR-017) IN PATIENTS WITH RELAPTSED/REFRACTORY MULTIPLE MYELOMA (POLARIS)
作者:Mingming Zhang, Yongxian Hu, Xiaomin Ding, Yu Tang, Yue Yang, Siye Chen, He Huang
发言人:He Huang
中国科学技术大学附属第一医院团队
这摘要号S264: CD19 + 复发性或难治性非霍奇金淋巴瘤非基因编辑同种异体CAR-T的初步分析
原标题:PRELIMINARY ANALYSES OF A NON-GENE-EDITING ALLOGENTIC CAR-T IN CD19+ RELAPSED OR REFRACTORY NON-HODGIN'S LYMPHOMA
作者:Xingbing Wang, Lei Xue , Sujun Li, Qian Fan, aichun Liu, Rong Jin, Xiaohui Yang, Tao Wang, Ling He, Jun Li
发言人: Lei Xue
以上oral均为中国研究者(暂不包括海外任职)领衔开展的研究,筛选自于EHA官网,若有遗漏,欢迎各位老师留言补充!谢谢!
排版编辑:Luna