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【ESMO 2022】LBA登陆消化道肿瘤专场,新辅助免疫再续前缘

2022年08月24日
编译:BREE
来源:肿瘤资讯

2022 ESMO大会即将于9月9日(欧洲中部夏令时间,CEST)在法国首都巴黎凡尔赛门展览馆开幕。

日前,含LBA在内的大会日程安排均已公布,「肿瘤资讯」整理了消化道领域入选本次ESMO大会LBA(Latest Breaking Abstract)的重磅研究,邀诸位一同细品!

专场:Proffered Paper session

Presidential Symposium II

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摘要号:LBA7

Neoadjuvant immune checkpoint inhibition in locally advanced MMR-deficient colon cancer: the NICHE-2 study

局部晚期 dMMR结肠癌的新辅助免疫检查点抑制:NICHE-2 研究

发言人:Myriam Chalabi (Amsterdam, Netherlands)

Proffered Paper session 1: GI, upper digestive

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摘要号:LBA34

Primary results from the phase 3 LEAP-002 study: lenvatinib plus pembrolizumab versus lenvatinib as first-line (1L) therapy for advanced hepatocellular carcinoma (aHCC)

 LEAP-002  3期研究的主要结果:仑伐替尼加帕博利珠单抗vs.仑伐替尼作为晚期肝细胞癌 (aHCC) 的一线 (1L) 治疗

发言人:Richard S. Finn (Los Angeles, United States of America) 

摘要号:LBA35

Camrelizumab (C) plus rivoceranib (R) vs. sorafenib (S) as first-line therapy for unresectable hepatocellular carcinoma (uHCC): a randomized, phase Ⅲ trial

卡瑞利珠单抗 (C) 加 rivoceranib (R) (即apatinib,阿帕替尼)vs.索拉非尼 (S) 作为不可切除肝细胞癌 (uHCC) 的一线治疗:一项随机 Ⅲ 期试验

发言人:秦叔逵,南京金陵医院,中国

摘要号:LBA36

Final Analysis of RATIONALE-301: Randomized, Phase 3 study of tislelizumab versus sorafenib as first-line treatment for unresectable hepatocellular carcinoma

RATIONALE-301 的最终分析:替雷利珠单抗与索拉非尼作为不可切除肝细胞癌一线治疗的随机 3 期研究

发言人:Masatoshi Kudo (Osaka, Japan)


Proffered Paper session 1: GI, lower digestive

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摘要号:LBA21

FOLFOX/FOLFIRI plus either bevacizumab or panitumumab in patients with initially unresectable colorectal liver metastases (CRLM) and left-sided and RAS/BRAFV600E wild-type tumour: phase III CAIRO5 study of the Dutch Colorectal Cancer Group

FOLFOX/FOLFIRI联合贝伐珠单抗或帕尼单抗治疗最初不可切除的结直肠肝转移 (CRLM) 、左侧、RAS/BRAFV600E野生型肿瘤患者:荷兰结直肠癌组的III期 CAIRO5研究

发言人:Marinde J. Bond (Utrecht, Netherlands)

摘要号:LBA22

Phase III study with FOLFIRI/Cetuximab versus FOLFIRI/Cetuximab followed by Cetuximab (Cet) alone in first-line therapy of RAS and BRAF wild-type (wt) metastatic colorectal cancer (mCRC) patients: the ERMES Study (NCT02484833).

FOLFIRI/西妥昔单抗序贯西妥昔单抗(Cet) vs. FOLFIRI/西妥昔单抗一线治疗RAS 和 BRAF 野生型(wt)转移性结直肠癌(mCRC)患者:ERMES III 期研究(NCT02484833)

发言人:Carmine Pinto (Reggio Emilia, Italy)


摘要号:LBA23

Avelumab versus standard second-line treatment chemotherapy in metastatic colorectal cancer (mCRC) patients with microsatellite instability (MSI): the SAMCO-PRODIGE 54 randomised phase II trial.

Avelumab vs. 标准二线化疗治疗微卫星不稳定性 (MSI) 转移性结直肠癌 (mCRC) 患者:SAMCO-PRODIGE 54 随机 II 期试验

发言人:Julien Taieb (Paris, France)

Proffered Paper session 2: GI, upper digestive
 

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摘要号:LBA12

Efficacy of RLY-4008, a highly selective FGFR2 inhibitor in patients (pts) with a FGFR2-fusion or rearrangement (f/r), FGFR inhibitor (FGFRi)-naïve cholangiocarcinoma (CCA): ReFocus trial

RLY-4008(一种高选择性 FGFR2 抑制剂)在 FGFR2 融合或重排 (f/r)、FGFR 抑制剂 (FGFRi) 初治胆管癌 (CCA) 患者 (pts) 中的疗效:ReFocus 试验

发言人:Antoine Hollebecque (Villejuif, Cedex, France)

摘要号:LBA60

Evaluation of gemcitabine and paclitaxel versus gemcitabine alone after FOLFIRINOX failure or intolerance in metastatic Pancreatic Ductal Adenocarcinoma: Results of the randomized phase III PRODIGE 65–UCGI 36–GEMPAX UNICANCER study

FOLFIRINOX治疗失败或不耐受后的转移性胰腺导管腺癌患者吉西他滨+紫杉醇vs.单独吉西他滨治疗的评估:随机 III 期 PRODIGE 65 - UCGI 36 - GEMPAX UNICANCER 研究的结果

发言人:Christelle De la Fouchardiere (Lyon, France) 

Proffered Paper session 2: GI, lower digestive

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摘要号:LBA24

KRYSTAL-1: updated efficacy and safety of adagrasib (MRTX849) with or without cetuximab in patients with advanced colorectal cancer (CRC) harboring a KRASG12C mutation  

KRYSTAL-1:adagrasib(MRTX849) 联合或不联合西妥昔单抗在携带 KRASG12C 突变的晚期结直肠癌 (CRC) 患者中的最新疗效和安全性

发言人:Samuel J. Klempner (Boston, United States of America)

摘要号:LBA25

FRESCO-2: A global phase 3 multiregional clinical trial (MRCT) evaluating the efficacy and safety of fruquintinib in patients with refractory metastatic colorectal cancer

FRESCO-2——一项全球 3 期多区域临床试验 (MRCT):评估呋喹替尼对难治性转移性结直肠癌患者的疗效和安全性

Proffered Paper session: NETs and endocrine tumours

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摘要号:LBA45

Randomized open label phase III study comparing the efficacy and safety of everolimus followed by chemotherapy (CT) with Streptozotocin (STZ)-5FU upon progression or the reverse sequence, in advanced progressive panNETs: the SEQTOR study (GETNE 1206)

在晚期进展性panNETs 中比较依维莫司序贯化疗 (CT) +链脲佐菌素 (STZ)-5FU的疗效和安全性 :随机开放标签 III 期SEQTOR 研究 (GETNE 1206) 

发言人:Ramon Salazar (Hospitalet de Llobregat, Spain)

Mini Oral session

 Mini Oral session: GI, upper digestive


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摘要号:LBA61

HR070803 plus 5-FU/LV versus placebo plus 5-FU/LV in second-line therapy for gemcitabine-refractory locally advanced or metastatic pancreatic cancer: a multicentered, randomized, double-blind, parallel-controlled phase III trial (HR-IRI-APC)

HR070803 + 5-FU/LV vs. 安慰剂 + 5-FU/LV 在吉西他滨难治性局部晚期或转移性胰腺癌的二线治疗效果:一项多中心、随机、双盲、平行对照的 III 期试验(HR -IRI-APC) 

发言人:王理伟教授,上海交通大学医学院附属仁济医院,中国

Mini Oral session: GI, lower digestive


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摘要号:LBA26

BREAKWATER safety lead-in (SLI): encorafenib (E) + cetuximab (C) + chemotherapy (chemo) for BRAFV600E metastatic colorectal cancer (mCRC)

BREAKWATER safety lead-in (SLI):encorafenib (E) + 西妥昔单抗 (C) +化疗 (chemo)用于 BRAFV600E 转移性结直肠癌 (mCRC) 

发言人:Josep Tabernero (Barcelona, Spain)

摘要号:LBA27

Additional analyses of MOUNTAINEER: A phase 2 study of tucatinib and trastuzumab for HER2-positive mCRC

MOUNTAINEER 2 期研究的其他分析:tucatinib和曲妥珠单抗治疗HER2 阳性 mCRC 

发言人:John H. Strickler (Durham, United States of America)

摘要号:LBA28

Prognostic effect of imaging and CEA follow-up in resected colorectal cancer (CRC): final results and relapse free survival (RFS) - PRODIGE 13 a FFCD phase III trial 

影像学和 CEA随访在已切除的结直肠癌 (CRC) 患者中的预后效果——最终结果和无复发生存期 (RFS): PRODIGE 13 FFCD III 期试验 

发言人:Come Lepage (Dijon, France) 

Mini Oral session: NETs and endocrine tumours

摘要号:LBA46

Bevacizumab (B) plus FOLFIRI after failure of platinum-etoposide in patients (pts) with advanced neuroendocrine carcinoma (NEC): the PRODIGE 41-BEVANEC randomized phase II study   

晚期神经内分泌肿瘤(NEC)患者(pts)铂类(依托泊苷)治疗失败后贝伐珠单抗 (B)+FOLFIRI治疗结果:PRODIGE 41-BEVANEC 随机 II 期研究

发言人:Thomas A. Walter (Lyon, France)

 

ESMO大会开幕在即,以上LBA哪一项最值得期待?快在评论区留言告诉我们吧!

 

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责任编辑:肿瘤资讯-Bree
排版编辑:肿瘤资讯-Morri


 


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2022年09月04日
邵宜
天津医科大学总医院 | 肿瘤内科
消化道肿瘤专场新辅助免疫