再放E彩第七期，小编今天带大家了解CAR-T细胞疗法治疗脑胶质瘤新进展，下面有请我们两位主持人，老放和小e。
*（以上信息可能涉及尚未在中国获批的产品/适应症，此信息仅作信息分享用途）
特别致谢黄煜伦教授
苏州大学附属独墅湖医院神经外科科室主任
中国抗癌协会胶质瘤专委会委员
江苏省抗癌协会神经肿瘤分会委员
江苏省医学会神经外科分会内镜学组委员
中国医药生物技术协会组织生物样本库分会PDX学组组员
江苏省神经科分会神经肿瘤与神经损伤专委会委员
1. Martinez M, Moon EK. CAR T Cells for Solid Tumors: New Strategies for Finding, Infiltrating, and Surviving in the Tumor Microenvironment. Front Immunol. 2019 Feb 5;10:128. doi: 10.3389/fimmu.2019.00128. PMID: 30804938; PMCID: PMC6370640.
2. Adachi K, Kano Y, Nagai T, Okuyama N, Sakoda Y, Tamada K. IL-7 and CCL19 expression in CAR-T cells improves immune cell infiltration and CAR-T cell survival in the tumor. Nat Biotechnol. 2018 Apr;36(4):346-351. doi: 10.1038/nbt.4086. Epub 2018 Mar 5. PMID: 29505028.
3. O'Rourke DM, Nasrallah MP, Desai A, Melenhorst JJ, Mansfield K, Morrissette JJD, Martinez-Lage M, Brem S, Maloney E, Shen A, Isaacs R, Mohan S, Plesa G, Lacey SF, Navenot JM, Zheng Z, Levine BL, Okada H, June CH, Brogdon JL, Maus MV. A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma. Sci Transl Med. 2017 Jul 19;9(399):eaaa0984. doi: 10.1126/scitranslmed.aaa0984. PMID: 28724573; PMCID: PMC5762203.
4. Ahmed N, Brawley V, Hegde M, Bielamowicz K, Kalra M, Landi D, Robertson C, Gray TL, Diouf O, Wakefield A, Ghazi A, Gerken C, Yi Z, Ashoori A, Wu MF, Liu H, Rooney C, Dotti G, Gee A, Su J, Kew Y, Baskin D, Zhang YJ, New P, Grilley B, Stojakovic M, Hicks J, Powell SZ, Brenner MK, Heslop HE, Grossman R, Wels WS, Gottschalk S. HER2-Specific Chimeric Antigen Receptor-Modified Virus-Specific T Cells for Progressive Glioblastoma: A Phase 1 Dose-Escalation Trial. JAMA Oncol. 2017 Aug 1;3(8):1094-1101. doi: 10.1001/jamaoncol.2017.0184. PMID: 28426845; PMCID: PMC5747970.
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Expire Date 2023/01/07
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