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BMS公布Checkmate-143研究结果,Opdivo治疗GBM未达到主要终点

2017年04月04日

2017年4月3日施贵宝公司(Bristol-Myers Squibb Company)(纽约证券交易所:BMY)今天宣布,CheckMate -143是一项随机的3期临床试验,评估了Opdivo在复发多形性胶质母细胞瘤患者中的疗效和安全性(GBM)未达到贝伐珠单抗单药治疗总体生存率改善的主要终点。这些数据将于2017年5月7日在瑞士苏黎世世界神经肿瘤学会联合会(WFNOS)上发布。

施贵宝医院的肿瘤发展主管,Fouad Namouni博士说:“GBM是一种历史上难以治疗的疾病,常规治疗方案表现出有限的反应。 “我们仍然坚定地追求治疗疾病的最高未满足的需求,并继续我们的工作,以确定我们的免疫肿瘤学代理人如何潜在地改善这些患者的结果。

CheckMate -143是GBM中首个采用PD-1检查点抑制剂的随机临床试验。 BMS有两个一线GBM临床试验,CheckMate -498和CheckMate -548,评估Opdivo与O6-甲基鸟嘌呤-DNA甲基转移酶(MGMT) - 甲基化和甲基化患者中放射治疗与/或不含替莫唑胺的组合。这些试验正在按计划前进。

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Bristol-Myers Squibb Announces Results from CheckMate -143, a Phase 3 Study of Opdivo (nivolumab) in Patients with Glioblastoma Multiforme 

MONDAY, APRIL 3, 2017 10:47 AM EDT 

PRINCETON, N.J.--(BUSINESS WIRE)--Bristol-Myers Squibb Company (NYSE:BMY) today announced that CheckMate -143, a randomized Phase 3 clinical trial evaluating the efficacy and safety of Opdivo in patients with first recurrence of glioblastoma multiforme (GBM), did not meet its primary endpoint of improved overall survival over bevacizumab monotherapy. These data will be presented on May 7, 2017 at the World Federation of Neuro-Oncology Societies (WFNOS) meeting in Zurich, Switzerland.

“GBM is a historically difficult disease to treat and conventional treatment options have demonstrated limited responses,” said Fouad Namouni, M.D., head of Oncology Development and head of Medical, Bristol-Myers Squibb. “We remain steadfast in our pursuit of treatments for diseases with the highest unmet need and continue our work to determine how our Immuno-Oncology agents can potentially improve outcomes for these patients.”

CheckMate -143 was the first randomized clinical trial in GBM with a PD-1 checkpoint inhibitor. BMS has two first-line GBM clinical trials, CheckMate -498 and CheckMate -548, evaluating the combination of Opdivo with radiation therapy with or without temozolomide in O6-methylguanine-DNA methyltransferase (MGMT)-unmethylated and methylated patients. These trials are moving forward as planned.

责任编辑:肿瘤资讯-小编


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