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2022 ESMO 大会肺癌LBA公布,ADAURA更新,免疫治疗独占鳌头!

2022年08月23日
编译:肿瘤资讯
来源:肿瘤资讯

2022 ESMO大会即将于9月9日(欧洲中部夏令时间,CEST)在法国首都巴黎凡尔赛门展览馆开幕。

日前,含LBA在内的大会日程安排均已公布,「肿瘤资讯」整理了会上将进行报告的肺癌研究,供参考。

Proffered Paper session & Presidential Symposium(按会议时间排序)

LBA37:一项随机、多中心2期研究(NEOpredict-Lung):可切除NSCLC患者中进行术前纳武利尤单抗单药或联合Relatlimab(LAG-3抑制剂)治疗

  • 原标题: A randomized, multicentric phase II study of preoperative nivolumab plus relatlimab or nivolumab in patients with resectable non-small-cell lung cancer (NEOpredict-Lung)

  • 报告专家:Martin H. Schuler (Essen, Germany)

LBA1:空气污染诱导的NSCLC的作用机制和可操作的炎症轴:走向分子癌症预防

  • 原标题:Mechanism of Action and an Actionable Inflammatory Axis for Air Pollution Induced Non-Small Cell Lung Cancer: Towards Molecular Cancer Prevention

  • 报告专家:Charles Swanton (London, United Kingdom)

LBA47:ADAURA更新,奥希替尼在可切除、IB-IIIA EGFR突变NSCLC中的新辅助治疗结局

  • 原标题:Osimertinib as adjuvant therapy in patients (pts) with resected EGFR-mutated (EGFRm) stage IB–IIIA non-small cell lung cancer (NSCLC): updated results from ADAURA

  • 报告专家:Masahiro Tsuboi (Kashiwa, Japan)

LBA48:基于社区的低剂量 CT 肺癌普查

  • 原标题:Community-based Mass Screening with Low-Dose CT for Lung Cancer in Guangzhou

  • 报告专家:梁文华教授(广州,中国)

950O :O+Y联合放化疗后进行手术,在可切除、临界可切除肺癌中的结果:INCREASE试验

  • 原标题:Ipilimumab plus Nivolumab and ChemoRadiotherapy followed by Surgery in patients with resectable and borderline resectable lung cancer: the INCREASE trial.

  • 报告专家:Idris Bahce (Amsterdam, Netherlands)

LBA49:CANOPY-A:canakinumab(CAN) 作为完全切除NSCLC辅助治疗的 III 期研究

  • 原标题:CANOPY-A: Phase III study of canakinumab (CAN) as adjuvant therapy in patients (pts) with completely resected non-small cell lung cancer (NSCLC)

  • 报告专家:Edward B. Garon (Santa Monica, United States of America)

1696O:肺癌脑转移的基因组分析和分子靶向分析

  • 原标题:Genomic profiling and molecular targeting of lung cancer brain metastases

  • 报告专家:Haiying Cheng (Bronx, United States of America)

LBA51:基于血浆 T790M 监测的EGFR 突变NSCLC奥希替尼治疗:EORTC lung cancer Group 1613 APPLE II期随机临床试验

  • 原标题:Osimertinib treatment based on plasma T790M monitoring in patients with EGFR-mutant non-small cell lung cancer (NSCLC): EORTC Lung Cancer Group 1613 APPLE phase II randomized clinical trial

  • 报告专家:Jordi Remon Masip (Barcelona, Spain)

LBA52:INSIGHT 2研究初步结果,Tepotinib联合奥希替尼一线治疗奥希替尼进展后的MET扩增EGFR突变NSCLC

  • 原标题:Tepotinib + osimertinib for EGFRm NSCLC with MET amplification (METamp) after progression on first-line (1L) osimertinib: Initial results from the INSIGHT 2 study

  • 报告专家:Julien Mazieres (Toulouse, France)

LBA53: ELIOS,一项EGFR突变晚期NSCLC一线奥希替尼治疗的多中心分子特征研究

  • 原标题:ELIOS: A multicentre, molecular profiling study of patients (pts) with epidermal growth factor receptor-mutated (EGFRm) advanced NSCLC treated with first-line (1L) osimertinib

  • 报告专家:Zofia Piotrowska (Boston, United States of America)

LBA54:EMPOWER-Lung 1研究的3年生存结局更新&晚期NSCLC化疗进展后使用Cemiplimab(CEMI)

  • 原标题:Three years survival outcome and continued cemiplimab (CEMI) beyond progression with the addition of chemotherapy (chemo) for patients (pts) with advanced non small cell lung cancer (NSCLC): the EMPOWER-Lung 1 trial

  • 报告专家:Mustafa Özgüroğlu (Istanbul, Turkey)


972O:O+Y 对比持续治疗6个月在晚期NSCLC的疗效:IFCT-1701 3期研究结果

  • 原标题:Nivolumab (Nivo) plus Ipilimumab (Ipi) 6-months treatment versus continuation in patients with advanced Non-Small-Cell-Lung Cancer (aNSCLC): results of the randomized IFCT-1701 phase 3 trial

  • 报告专家:Gerard Zalcman (Paris, CEDEX 18, France)

LBA11:IPSOS:一线阿替利珠单抗 vs 单药化疗治疗不适用铂类化疗NSCLC的3期研究

  • 原标题:IPSOS: Results from a Phase 3 study of first-line (1L) atezolizumab (atezo) vs single-agent chemotherapy (chemo) in patients (pts) with NSCLC not eligible for a platinum-containing regimen

  • 报告专家:Siow Ming Lee (London, United Kingdom)

Mini Oral session

LBA55:DESTINY-Lung02 2期研究初步结果,T-DXd应用于HER2突变NSCLC

  • 原标题:Trastuzumab Deruxtecan (T-DXd) in Patients (Pts) With HER2-Mutant Metastatic Non–Small Cell Lung Cancer (NSCLC): Interim Results From the Phase 2 DESTINY-Lung02 Trial

  • 报告专家:Koichi Goto (Kashiwa, Japan)

LBA56:MEDI5752或帕博利珠单抗联合卡铂/培美曲塞(CP)一线治疗NSCLC:一项1b/2期研究

  • 原标题:MEDI5752 or pembrolizumab (P) plus carboplatin/pemetrexed (CP) in treatment-naïve (1L) non-small cell lung cancer (NSCLC): a Phase 1b/2 trial

  • 报告专家:Myung-Ju Ahn (Seoul, Korea, Republic of)

LBA57:信迪利单抗联合安罗替尼 vs 铂类化疗,一线治疗转移性NSCLC(SUNRISE):一项开放标签、多中心随机2期研究

  • 原标题:Sintilimab plus anlotinib versus platinum-based chemotherapy as first-line therapy in metastatic NSCLC (SUNRISE): an open label, multi-center, randomized, phase 2 study

  • 报告专家:韩宝惠(上海,中国)

LBA58:信迪利单抗联合或不联合 IBI305 + 化疗治疗 EGFR TKI进展的 EGFR 突变非鳞NSCLC:III期 ORIENT-31 研究第二次中期分析

  • 原标题:Sintilimab with or without IBI305 plus chemotherapy in patients with EGFR mutated non-squamous non-small-cell lung cancer (EGFRm nsqNSCLC) who progressed on EGFR tyrosine-kinase inhibitors (TKIs) therapy: second interim analysis of phase 3 ORIENT-31 study

  • 报告专家:陆舜(上海,中国)

LBA59:度伐利尤单抗±tremelimumab一线治疗转移性NSCLC,POSEIDON研究的4年随访OS更新

  • 原标题:Durvalumab (D) ± tremelimumab (T) + chemotherapy (CT) in 1L metastatic (m) NSCLC: overall survival (OS) update from POSEIDON after median follow-up (mFU) of approximately 4 years (y)

  • 报告专家:Melissa L. Johnson (Nashville, United States of America)

973MO:KEYNOTE-189 5年随访更新:帕博利珠单抗+培美曲塞+铂类一线治疗转移性非鳞NSCLC

  • 原标题:KEYNOTE-189 5-year update: first-line pembrolizumab (pembro) + pemetrexed (pem) and platinum vs placebo (pbo) + pem and platinum for metastatic nonsquamous NSCLC

  • 报告专家:Marina C. Garassino (Chicago, United States of America)

974MO:KEYNOTE-407 5年随访更新,帕博利珠单抗与化疗在鳞状NSCLC中的对比

  • 原标题:5-Year Update From KEYNOTE-407: Pembrolizumab Plus Chemotherapy in Squamous Non‒Small-Cell Lung Cancer (NSCLC)

  • 报告专家:Silvia Novello (Orbassano, Italy)

LBA71:O+Y vs 化疗在不可切除的恶性胸膜间皮瘤 (uMPM) 患者中的比较:CheckMate 743的4年更新

  • 原标题:First–line nivolumab (NIVO) plus ipilimumab (IPI) vs chemotherapy (chemo) in patients (pts) with unresectable malignant pleural mesothelioma (uMPM): 4-year update from CheckMate 743

  • 报告专家:Gerard Zalcman (Paris, France)


930MO:PEARLS/KEYNOTE-091亚组分析:在完全切除术后IB-IIIA期患者中,帕博利珠单抗与安慰剂组的PD-L1表达与结局
  • 原标题:PD-L1 expression and outcomes of pembrolizumab and placebo in completely resected stage IB-IIIA NSCLC: subgroup analysis of PEARLS/KEYNOTE-091

  • 报告专家:Solange Peters (Lausanne, Switzerland)

931MO:JIPANG 3期研究最终OS分析:完全切除非鳞NSCLC中培美曲塞/顺铂 vs 长春瑞滨/顺铂

  • 原标题:Final overall survival analysis of phase III study of pemetrexed/cisplatin versus vinorelbine/cisplatin for completely resected non-squamous non-small-cell lung cancer: the JIPANG Study

  • 报告专家:Kiyotaka Yoh (Kashiwa, Chiba, Japan)

929MO:度伐利尤单抗单药或联合新药在可切除、早期NSCLC中进行新辅助治疗的平台研究:NeoCOAST研究中的药效学与ctDNA动力学

  • 原标题:Platform study of neoadjuvant durvalumab (D) alone or combined with novel agents in patients (pts) with resectable, early-stage non-small-cell lung cancer (NSCLC): pharmacodynamic correlates and circulating tumor DNA (ctDNA) dynamics in the NeoCOAST study

  • 报告专家:Jonathan Spicer (Montreal, Canada)

LBA50:纳武利尤单抗联合含铂双药化疗 vs 化疗,对可切除NSCLC进行新辅助治疗:来自 CheckMate 816 的健康相关生活质量 (HRQoL) 结局

  • 原标题:Nivolumab (NIVO) plus platinum-doublet chemotherapy (chemo) versus chemo as neoadjuvant treatment for resectable non-small cell lung cancer (NSCLC): health-related quality of life (HRQoL) outcomes from CheckMate 816

  • 报告专家:Enriqueta Felip (Barcelona, Spain)

1529MO:从不吸烟小细胞肺癌患者的基因组图谱

  • 原标题:The genomic landscape of small cell lung cancer in never smoking patients

  • 报告专家:Michael Oh (Los Angeles, United States of America)

933MO:纵向监测根治性切除的 IA-IIIA 期 EGFR 突变非小细胞肺癌患者血浆循环肿瘤 DNA

  • 原标题:Longitudinal monitoring of circulating tumor DNA from plasma in patients with curative resected stage IA-IIIA EGFR mutant non-small cell lung cancer

  • 报告专家:Myung-Ju Ahn (Seoul, Korea)

905MO:临床、影像学和 DNA 甲基化生物标志物的协同结合改善肺结节分类

  • 原标题:Synergistic Combination of Clinical, Imaging and DNA Methylation Biomarkers Improves the Classification of Pulmonary Nodules

  • 报告专家:梁文华(广州,中国)

责任编辑:肿瘤资讯-Shire
排版编辑:肿瘤资讯-Shire

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2022年08月28日
尹青
淄博市周村区人民医院 | 病理科
08-23 2022 ESMO 大会肺癌LBA公布,ADAURA更新,免疫治疗独占鳌头!
2022年08月28日
尹青
淄博市周村区人民医院 | 病理科
08-23 2022 ESMO 大会肺癌LBA公布,ADAURA更新,免疫治疗独占鳌头!
2022年08月28日
尹青
淄博市周村区人民医院 | 病理科
08-23 2022 ESMO 大会肺癌LBA公布,ADAURA更新,免疫治疗独占鳌头!