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复旦全面阐述乳腺癌春秋与战国策

02月20日

来源：SIBCS，信号转导靶向治疗

乳腺癌具有独特的流行病学特征和显著的多样性，也是女性死于恶性肿瘤的主要原因之一。乳腺癌分子亚型的日益细分化提高了人们对该疾病的认识水平和精准治疗水平。乳腺癌的发生发展机制一直是科学研究工作的重点，内容涵盖肿瘤干细胞、肿瘤内微生物群、昼夜节律等多个角度。技术进步，尤其是与人工智能相结合的进步，大大提高了乳腺癌检测和诊断的准确性。新的治疗理念和药物的出现，代表了医疗向个体化方向的转变。证据表明，针对患者个体风险和预期亚型量身定制诊断和治疗的最佳方式至关重要，有助于乳腺癌精准肿瘤学时代的到来。虽然肿瘤学进展迅速，乳腺癌的临床精准治疗越来越受到重视，但是仍然需要对该疾病相关各方面知识进行全面的更新和总结。

2025年2月19日，英国《自然》旗下《信号转导与靶向治疗》在线发表复旦大学附属肿瘤医院熊鑫①、郑乐葳①、陈雨霏①、蔡毓文①、王磊苹、黄亮、刘翠翠、邵志敏、余科达、贵阳市妇幼保健院丁彧①等学者的长篇综述，全面回顾了乳腺癌的流行病学、风险因素、临床和病理生理学特征、肿瘤发生的变异性和分子亚型、复发转移耐药机制、诊断技术进步，并详细介绍了乳腺癌新型治疗策略和患者长期生活质量管理的研究进展。全文共计3.6万余字，长达32页，参考文献多达558篇。该综述为乳腺癌研究最新进展提供了真知灼见，有助于推动未来基础研究和临床应用的发展。

Signal Transduct Target Ther. 2025 Feb 19;10:49. IF: 40.8

Breast cancer: pathogenesis and treatments.

Xiong X, Zheng LW, Ding Y, Chen YF, Cai YW, Wang LP, Huang L, Liu CC, Shao ZM, Yu KD.

Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China; Guiyang Maternal and Child Health Care Hospital & Guiyang Children's Hospital, Guiyang, China; Guizhou Medical University, Guiyang, China.

Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes of malignancy-related deaths in women. The increasingly nuanced molecular subtypes of breast cancer have enhanced the comprehension and precision treatment of this disease. The mechanisms of tumorigenesis and progression of breast cancer have been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, and circadian rhythms. Technological advancements, particularly those integrated with artificial intelligence, have significantly improved the accuracy of breast cancer detection and diagnosis. The emergence of novel therapeutic concepts and drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis and treatment models tailored to individual patient risk and expected subtypes are crucial, supporting the era of precision oncology for breast cancer. Despite the rapid advancements in oncology and the increasing emphasis on the clinical precision treatment of breast cancer, a comprehensive update and summary of the panoramic knowledge related to this disease are needed. In this review, we provide a thorough overview of the global status of breast cancer, including its epidemiology, risk factors, pathophysiology, and molecular subtyping. Additionally, we elaborate on the latest research into mechanisms contributing to breast cancer progression, emerging treatment strategies, and long-term patient management. This review offers valuable insights into the latest advancements in Breast Cancer Research, thereby facilitating future progress in both basic research and clinical application.

PMID : 39966355

DOI : 10.1038/s41392-024-02108-4

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02月27日

颜昕

漳州市医院 | 乳腺外科

阐述乳腺癌春秋与战国策