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肿瘤免疫的未来和思考？

2019年01月22日

来源：肺癌前沿

屏幕快照 2019-01-22 下午6.46.31.png Revisiting Immunity Circle

2017年1月，仍在Genentech供职的Daniel S. Chen& Ira Mellman 在Nature上发表了一篇名为.“

Elements of cancer immunity and the cancer–immune set point”的review article，从此学界（在中国主要是会议界）开始学会用一种全新的极简的方法逻辑来描述肿瘤免疫。Immune phenotype, immunity circle 以各种“appearance”花式出现在各种会议上，被奉为圭臬。

复杂逻辑的分类学往往源于观测到的简单现象，比如现在的肿瘤-免疫分型方法即建立在下图的现象描述上。

Approaches to treat immune hot, altered and cold tumors with combination immunotherapies.Jérôme Galon & Daniela Bruni

Nature Reviews Drug Discovery (2019)

Fig. 1 | Defining ‘hot,’ ‘altered’ and ‘cold’ immune tumors — Immunoscore as a new approach to the classification of cancer.

Quote 2019:

在这些发现的基础上，提出并采用了“免疫背景”的新概念，以指代将免疫细胞的性质，密度，免疫功能定向和分布相关联的免疫变量的组合。

这些免疫背景参数与长期存活和对治疗的响应的预测相关.

这种tumor-immune classification方式，是对肿瘤与免疫系统复杂的相互作用的极简化“描述”处理。

从下列这个简化的罗列中能看到部分免疫细胞和化学因子的参与。

在2017年，我们看到的是3型

Elements of cancer immunity and the cancer–immune set point.Daniel S. Chen& Ira Mellman Nature volume541, pages321–330 (19 January 2017)

Anticancer immunity in humans can be segregated into three main phenotypes: the immune-desert phenotype (brown), the immune–excluded phenotype (blue) and the inflamed phenotype (red). Each is associated with specific underlying biological mechanisms that may prevent the host's immune response from eradicating the cancer.

A map of cancer immunity showing the factors that affect the cancer–immune set point. The factors are placed on rings that denote their type, and each factor is also placed in the step of the cancer-immunity cycle in which they mainly act.