2026年美国癌症研究协会(AACR)年会将于4月17至22日在美国圣地亚哥举行。作为全球规模最大的肿瘤学研究盛会之一,AACR汇聚了来自世界各地的顶级科学家、临床医生及创新药研发者,共同探讨从基础研究到临床转化的最新突破。
目前大会官网已公布摘要标题,【肿瘤资讯】特此整理了本届大会中消化道肿瘤领域的12项重磅口头报告(Plenary Session/Minisymposium),涵盖胃癌、食管癌、肝癌、结直肠癌及胰腺癌等消化道肿瘤领域的最新研究成果,以飨诸君。
Late-Breaking Minisymposium
摘要号:LB407 / 7
英文标题:Daraxonrasib plus chemotherapy (CT) as first-line (1L) treatment for patients (Pts) with metastatic pancreatic adenocarcinoma (mPDAC).
中文标题:Daraxonrasib联合化疗一线治疗转移性胰腺导管腺癌(mPDAC)患者
讲者:Brian Wolpin
医院:丹娜-法伯癌症研究所
Clinical Trials Plenary Session
摘要号:CT105
英文标题:FAP-targeted 4-1BBL trimeric costimulation amplifies T-cell activation and antitumor efficacy of a CEA-directed T-cell engager in MSS colorectal cancer.
中文标题:FAP靶向的4-1BBL三聚体共刺激可增强CEA靶向T细胞衔接器在MSS结直肠癌中的T细胞激活及抗肿瘤疗效
讲者:I. Melero
医院:西班牙纳瓦拉大学(Clínica Universidad de Navarra)
摘要号:CT230
英文标题:STRIDE regimen of tremelimumab and durvalumab as non-operative management strategy of microsatellite instability-high (MSI-H) resectable gastric or gastroesophageal junction adenocarcinoma (GAC/GEJAC): Final results of the cohort 2 of INFINITY study by GONO GI.
中文标题:tremelimumab联合度伐利尤单抗(STRIDE方案)作为MSI-H型可切除胃或胃食管结合部腺癌(GAC/GEJAC)的非手术管理策略:GONO GI研究组INFINITY研究队列2的最终结果
讲者:Alberto Giovanni Leone
医院:意大利米兰IRCCS国家肿瘤研究所基金会
Clinical Trials Minisymposium
摘要号:CT011
英文标题:Genomic HER2 amplification predicts for complete clinical response in a phase II study of induction tucatinib and trastuzumab combined with chemotherapy in locally advanced rectal adenocarcinoma.
中文标题:基因组HER2扩增可预测局部晚期直肠腺癌在tucatinib、曲妥珠单抗联合化疗诱导治疗后的临床完全缓解(cCR):一项II期研究结果
讲者:M. B. Foote
医院:美国纪念斯隆凯特琳癌症中心(MSKCC)
摘要号:CT016
英文标题:Feasibility and efficacy of perioperative nivolumab with or without relatlimab for patients with potentially resectable hepatocellular carcinoma.
中文标题:纳武利尤单抗(Nivolumab)联合或不联合Relatlimab用于潜在可切除肝细胞癌患者围手术期治疗的可行性与疗效
讲者:H. L. Li
医院:美国Sidney Kimmel综合癌症中心
摘要号:CT026
英文标题:A phase I trial of intraperitoneal (IP) mesothelin (MSLN)-targeted CAR T-cell therapy in patients with MSLN-positive esophagogastric cancer (EGC) with peritoneal carcinomatosis.
中文标题:腹腔内(IP)间皮素(MSLN)靶向CAR-T细胞疗法治疗伴有腹膜转移的MSLN阳性食管胃癌(EGC)患者的I期试验
讲者:Joan Choo
医院:美国纪念斯隆凯特琳癌症中心
摘要号:CT027
英文标题:Safety and preliminary efficacy of a novel LACO-Stim armored mesothelin-targeted CART therapy in advanced solid tumors.
中文标题:一种新型LACO-Stim“装甲型”间皮素靶向CAR-T疗法治疗晚期实体瘤的安全性和初步疗效
讲者:齐长松
医院:北京大学肿瘤医院
摘要号:CT030
英文标题:A phase 1b/2a, open-label, multicenter, randomized, dose escalation study evaluating the safety, tolerability and efficacy of RZ-001 in combination with valganciclovir (VGCV) and atezolizumab/bevacizumab in subjects with hepatocellular carcinoma.
中文标题:一项Ib/IIa期、开放标签、多中心、随机、剂量递增研究:评估RZ-001联合缬更昔洛韦(VGCV)及阿替利珠单抗+贝伐珠单抗治疗肝细胞癌的安全性、耐受性与有效性
讲者:Yoon Jun Kim
医院:韩国首尔国立大学医院
摘要号:CT031
英文标题:A phase I/II trial evaluating LOAd703 in combination with nab-paclitaxel, gemcitabine, and atezolizumab for advanced pancreatic cancer.
中文标题:一项评估LOAd703联合白蛋白结合型紫杉醇、吉西他滨和阿替利珠单抗治疗晚期胰腺癌的I/II期试验
讲者:Angelica Loskog
医院:瑞典乌普萨拉(Uppsala)大学
摘要号:CT170
英文标题:Neoadjuvant pembrolizumab stratified by tumor mutation burden in high-risk stage II-III dMMR/MSI-H colorectal cancer (NEOPRISM-CRC): Perioperative ultrasensitive ctDNA monitoring and tumor-infiltrating TCR repertoire for treatment response prediction.
中文标题:高危II-III期dMMR/MSI-H结直肠癌(NEOPRISM-CRC)中基于TMB分层的帕博利珠单抗新辅助治疗:围手术期超灵敏ctDNA监测及肿瘤浸润TCR谱对治疗反应的预测作用
讲者:Yanrong Jiang
医院:英国伦敦大学学院(UCL)癌症研究所
摘要号:CT303
英文标题:Safety and efficacy of Elisrasib (D3S-001), a next generation GDP-bound KRAS G12C inhibitor, as monotherapy or combination therapy with cetuximab in previously treated metastatic CRC and PDAC: Results from a phase 1/2 study.
中文标题:新一代GDP结合型KRAS G12C抑制剂Elisrasib (D3S-001)单药或联合西妥昔单抗治疗经治转移性结直肠癌(mCRC)及胰腺导管腺癌(PDAC)的安全性和有效性:I/II期研究结果
讲者:Kanwal Raghav
医院:美国德克萨斯大学MD安德森癌症中心
摘要号:CT304
英文标题:Narmafotinib (AMP945) in combination with gemcitabine and nab-paclitaxel in first-line patients with advanced pancreatic cancer (ACCENT trial) a Phase 1b/2a study-Interim analysis.
中文标题:Narmafotinib (AMP945)联合吉西他滨和白蛋白结合型紫杉醇一线治疗晚期胰腺癌(ACCENT试验):一项Ib/IIa期研究的中期分析
讲者:Terrie-Anne Cock
医院:澳大利亚墨尔本Amplia Therapeutics
排版编辑:肿瘤资讯-ZJN






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