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【2023 ASCO】 儿童肿瘤重磅研究一文速览!

2023年05月10日
编译:肿瘤资讯
来源:肿瘤资讯

2023年第59届美国临床肿瘤学会(ASCO)年会将于美国芝加哥当地时间6月2~6日举行,一年一度的学术盛宴将启。ASCO官网已公布会议日程和摘要题目。
【肿瘤资讯】特别整理口头摘要专场(Oral Abstract Session)、壁报交流专场(Poster Discussion Session)的儿童肿瘤研究,与临床医生分享。


口头摘要专场(Oral Abstract Session)


摘要号:10000

HR-NBL1/SIOPEN试验中微型营养评定和小于18个月的高危神经母细胞瘤患者的研究结果

High risk neuroblastoma (HR-NB) with MNA and age <18 months: Results from the HR-NBL1/SIOPEN trial.   

讲者:Ruth Lydia Ladenstein, MD, MBA | St. Anna Children's Hospital and St. Anna Kinderkrebsforschung, Department of Paediatrics, Medical University Vienna


摘要号:10001

伊立替康和替莫唑胺联合达沙替尼和雷帕霉素治疗复发或难治性神经母细胞瘤患者:前瞻性随机RIST试验结果

Irinotecan and temozolomide combined with dasatinib and rapamycin for patients with relapsed or refractory neuroblastoma: Results of the prospective randomized RIST trial.

讲者:Selim Corbacioglu, MD PhD | University Hospital of Regensburg


摘要号:10002

一项高危神经母细胞瘤晚期影响的多中心合作组COG ALTE15N2-LEAHRN研究

A multicenter cooperative group study of late effects after high-risk neuroblastoma: COG ALTE15N2—LEAHRN study.

讲者:Tara O. Henderson, MD, FASCO, MPH | The University of Chicago


摘要号:10003

用于根除弥漫内生型脑桥胶质瘤(DIPG)的生物药物(BIOMEDE):一项比较了ITCC、SIOPE Brain和ANZCHOG的3种靶向疗法联合放射疗法的国际随机II期平台试验的最终结果

Biological Medicines for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication (BIOMEDE): Final results of an international randomized phase II platform trial comparing 3 targeted therapies in combination with radiotherapy from ITCC, SIOPE-Brain and ANZCHOG.

讲者:Jacques Grill, MD, PhD | Gustave Roussy


摘要号:10004

泛RAF抑制剂托沃拉非尼在2期FIREFLY-1(PNOC026)研究登记的儿科低级别神经胶质瘤中的临床活性

Clinical activity of pan-RAF inhibitor tovorafenib in the registrational pediatric low-grade glioma arm of the phase 2 FIREFLY-1 (PNOC026) study.

讲者:Lindsay Baker Kilburn, MD | Children's National Hospital


摘要号:10005

局灶性间变型肾母细胞瘤(FAWT)的治疗:来自儿童肿瘤学组(COG)AREN0321和AREN03B2研究的报告

Treatment of focal anaplastic Wilms tumor (FAWT): A report from the Children’s Oncology Group (COG) AREN0321 and AREN03B2 studies.

讲者:Amy E. Armstrong, MD | Washington University in St Louis


摘要号:10006

哌柏西利用于细胞周期蛋白D-CDK 4/6-INK 4a-Rb通路基因组改变的实体瘤患者:NCI-COG儿科MATCH试验I组(APEC 1621 I)的结果

Palbociclib in solid tumor patients with genomic alterations in the cyclin D-CDK4/6-INK4a-Rb pathway: Results from NCI-COG Pediatric MATCH trial Arm I (APEC1621I).

讲者:Margaret E Macy, MD | Department of Pediatrics, University of Colorado and Center for Cancer and Blood Disorders, Children’s Hospital Colorado


摘要号:10007

厄达替尼在FGFR突变肿瘤患者中的应用:NCI-COG儿科MATCH试验B组(APEC 1621 B)结果

Erdafitinb in patients with FGFR-altered tumors: Results from the NCI-COG Pediatric MATCH trial arm B (APEC1621B).

讲者:Alice Lee, MD | Children's Hospital at Montefiore


摘要号:10008

拉罗替尼在新诊断婴儿纤维肉瘤(IFS)中的II期研究:儿童肿瘤学组(COG)ADVL1823队列A

Phase 2 study of larotrectinib in children with newly diagnosed infantile fibrosarcoma (IFS): Children’s Oncology Group (COG) ADVL1823 cohort A.

讲者:Theodore Willis Laetsch, MD | Division of Oncology, Children’s Hospital of Philadelphia, and Abramson Cancer Center, University of Pennsylvania


摘要号:10009

针对贫困儿童癌症资源公平(PediCARE)干预的可行性

Feasibility of the Poverty-Targeted Pediatric Cancer Resource Equity (PediCARE) intervention.

讲者:Haley Newman, MD | Children's Hospital of Philadelphia


摘要号:10010

儿童肿瘤学组试验背景下健康数据收集的社会决定因素的可行性和可接受性

Feasibility and acceptability of social determinants of health data collection in the context of a Children’s Oncology Group trial.

讲者:Emily Jones, BS | Dana-Farber/Boston Children’s Cancer and Blood Disorders Center


摘要号:10011

美国医疗补助扩大后儿童癌症的成年幸存者:儿童癌症幸存者研究(CCSS)报告

Medicaid enrollment changes among U.S. adult survivors of childhood cancer following Medicaid expansion: A report from the Childhood Cancer Survivor Study (CCSS). 

讲者:Xu Ji, PhD | Emory University School of Medicine 


摘要号:10012

通过监测超声心动图增强对癌症治疗相关心肌病的预测:儿童肿瘤学组(COG)报告

Enhancing prediction of cancer therapy-related cardiomyopathy from surveillance echocardiograms: A Children’s Oncology Group (COG) report.

讲者:Eric Jessen Chow, MD, MPH | Fred Hutchinson Cancer Center


摘要号:10013

卡维地洛用于预防蒽环类药物暴露的儿童癌症幸存者的心力衰竭:来自COG ALTE1621的结果

Carvedilol for prevention of heart failure in anthracycline-exposed survivors of childhood cancer: Results from COG ALTE1621.

讲者:Saro Armenian, DO, MPH | City of Hope


摘要号:10014

儿童癌症幸存者的克隆性造血

Clonal hematopoiesis in survivors of childhood cancer.

讲者:Danielle Novetsky Friedman, MD | Memorial Sloan Kettering Cancer Center


摘要号:10015

急性淋巴细胞白血病预后的基因组决定因素:儿童肿瘤学组的研究

Genomic determinants of outcome in acute lymphoblastic leukemia: A Children’s Oncology Group study.

讲者:Ti-Cheng Chang, PhD | St. Jude Children’s Research Hospital


摘要号:10016

奥加伊妥珠单抗治疗高危B淋巴母细胞白血病的3期试验:儿童肿瘤学组AALL 1732研究的第二安全性阶段结果

A phase 3 trial of inotuzumab ozogamicin for high-risk B-ALL: Second safety phase results from Children’s Oncology Group AALL1732.

讲者:Maureen Megan O'Brien, MD, MS | Cincinnati Children's Hospital Medical Center

 

摘要号:10017

博舒替尼在新诊断慢性骨髓性白血病(CML)儿童患者中的首次II期试验(ITCC-054/COG-AAML 1921)初步结果

Preliminary results from the first-in-child phase II trial (ITCC-054/COG-AAML1921) of bosutinib in pediatric patients with newly diagnosed (ND) chronic myeloid leukemia (CML).

讲者:Edoardo Pennesi | Erasmus MC


壁报交流专场(Poster Discussion Session)


摘要号:10018 | Poster Bd #: 324

在德克萨斯州KidsCanSeq研究中,通过肿瘤基因组检测儿童癌症患者中具有临床意义的分子改变的频率和频谱

Frequency and spectrum of clinically significant molecular alterations detected by tumor gene panel testing for pediatric cancer patients in the Texas KidsCanSeq study.

讲者:Frank Y. Lin, MD | Texas Children's Cancer and Hematology Center, Baylor College of Medicine


摘要号:10019 | Poster Bd #: 325

法国儿童和青少年使用经验性抗癌疗法同情用药的综合性全国性研究

Comprehensive nationwide study on the prescription of experimental anticancer therapies for compassionate use in children and adolescents in France.

讲者:Pablo Berlanga, MD PhD | Gustave Roussy Cancer Campus


摘要号:10020 | Poster Bd #: 326

在靶向和免疫治疗时代,参与肿瘤学试验的儿童和青少年早期死亡率的预后因素:一项儿童癌症创新疗法(ITCC)研究

Prognostic factors of early mortality in children and adolescents enrolled in oncology trials with a dose-finding part in the era of targeted and immune therapies: An Innovative Therapies for Children with Cancer (ITCC) study.

讲者:Fernando Carceller | The Royal Marsden NHS Foundation Trust


摘要号:10021 | Poster Bd #: 327

儿童神经肿瘤患者生命末期的强度:儿科姑息治疗案例

Intensity at the end of life in pediatric neuro-oncology patients: The case for pediatric palliative care.

讲者:Chinwe Udemgba | University of Chicago


摘要号:10022 | Poster Bd #: 328

使用5-羟甲基胞嘧啶谱鉴定无细胞DNA中的骨肉瘤特征

Identifying osteosarcoma signatures in cell free DNA using 5-hydroxymethylcytosine profiling.

讲者:Evan W Neczypor, BS | University of Chicago Pritzker School of Medicine


摘要号:10023 | Poster Bd #: 329

FCN-159在儿童1型神经纤维瘤病患者中的安全性和有效性:一项多中心、开放标签、单臂1/2期研究

A multicenter, open-label, single-arm phase 1/2 study to evaluate the safety and efficacy of FCN-159 in pediatric participants with neurofibromatosis type 1.

讲者:Xiaojie Hu, MD | Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine(上海交通大学医学院附属第九人民医院 胡晓洁)


摘要号:10024 | Poster Bd #: 330

西罗莫司联合节拍化疗(CHOAnome)治疗复发性和/或难治性实体瘤和中枢神经系统肿瘤儿童的2期研究

A phase 2 study of sirolimus in combination with metronomic chemotherapy (CHOAnome) in children with recurrent and/or refractory solid and CNS tumors.

讲者:Thomas Cash, MD, MSc | Aflac Cancer & Blood Disorders Center, Children’s Healthcare of Atlanta, Emory University School of Medicine


摘要号:10025 | Poster Bd #: 331

B型急性淋巴细胞白血病患儿在维持期内每4周和12周随机接受一次长春新碱/地塞米松治疗的身体和情感生活质量:儿童肿瘤学组AALL0932

Physical and emotional quality of life in children with B-acute lymphoblastic leukemia randomized to every 4- vs. 12-week vincristine/dexamethasone during maintenance: Children’s Oncology Group AALL0932.

讲者:Nina S. Kadan-Lottick, MD, MSPH | Georgetown University Lombardi Comprehensive Cancer Center


摘要号:10026 | Poster Bd #: 332

CAR T细胞治疗的儿科肿瘤学家转诊实践:一项混合方法研究

Pediatric oncologist referral practices for CAR T-cell therapy: A mixed methods study.

讲者:Anurekha Gollapudi Hall, MD, MS | Seattle Children's Hospital, University of Washington


摘要号:10027 | Poster Bd #: 333

一项2期、开放标签、KEYNOTE-667研究中,帕博利珠单抗治疗一线化疗早期不敏感的新诊断霍奇金淋巴瘤儿童和年轻成人的疗效和安全性

Efficacy and safety of pembrolizumab (pembro) in children and young adults with newly diagnosed classical Hodgkin lymphoma (cHL) with slow early response (SER) to front-line chemotherapy (chemo) in the phase 2, open-label, KEYNOTE-667 study.

讲者:Luciana Vinti, MD, PhD | IRCCS Ospedale Pediatrico Bambino Gesu


摘要号:10028 | Poster Bd #: 334

儿童癌症成年幸存者的脑老化加速和相关的神经认知障碍

Accelerated brain age and associated neurocognitive impairments in adult survivors of childhood cancer.

讲者:Nicholas Steve Phillips, MD, PhD | St. Jude Children's Research Hospital


摘要号:10029 | Poster Bd #: 335

不同儿童癌症幸存者中2型糖尿病患病风险的遗传学研究:来自St. Jude Lifetime队列(SJLIFE)和儿童癌症幸存者研究(CCSS)

Genetic study of type 2 diabetes risk in diverse populations of survivors of childhood cancer: A report from the St. Jude Lifetime Cohort (SJLIFE) and the Childhood Cancer Survivor Study (CCSS).

讲者:Cindy Im, PhD | University of Minnesota


(本文依照报告日期和出场排序整理,如有错误或遗漏,敬请留言指正。)


参考文献

https://meetings.asco.org/meetings/2023-asco-annual-meeting/299/program-guide/scheduled-sessions?filters=%7B%22track%22:%5B%7B%22key%22:%22Pediatric%20Oncology%22%7D%5D%7D



责任编辑:肿瘤资讯-云初
排版编辑:肿瘤资讯-云初


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评论
2023年05月12日
吴枫阳
湖北省肿瘤医院 | 消化内科
2023 ASCO 儿童肿瘤重磅研究
2023年05月12日
陈周行
湖南旺旺医院 | 肿瘤科
【2023 ASCO】 儿童肿瘤重磅研究一文速览!
2023年05月12日
潘雪峰
中国人民解放军联勤保障部队第九八九医院 | 肿瘤科
好好学习,天天向上