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【2023 ASCO】前沿速递!一文纵览肉瘤重磅研究

2023年05月06日
整理:肿瘤资讯
来源:肿瘤资讯

2023年第59届美国临床肿瘤学会(ASCO)年会将于美国芝加哥当地时间6月2~6日举行,一年一度的学术盛宴将启。ASCO官网已公布会议日程和摘要题目。【肿瘤资讯】特别整理口头报告专场(Oral Abstract Session)、临床科学研讨会(Clinical Science Symposium),以及壁报讨论专场(Poster Discussion Session)的肉瘤研究,揭秘前沿进展。

口头报告专场(Oral Abstract Session)

摘要号:11500

纳武利尤单抗联合trabectedin用于经治晚期软组织肉瘤(STS)患者的疗效和安全性:德国跨学科肉瘤小组(GISG-15, NitraSarc)的II期试验结果

Efficacy and safety of nivolumab and trabectedin in pretreated patients with advanced soft tissue sarcomas (STS): Results of a phase II trial of the German Interdisciplinary Sarcoma Group (GISG-15, NitraSarc).

讲者: Peter Reichardt, MD, PhD | HELIOS Klinikum Berlin-Buch, Klinik für Interdisziplinäre Onkologie, Sarkomzentrum Berlin-Brandenburg


摘要号:11501

多柔比星+CTLA-4抑制剂Zalifrelimab+PD-1抑制剂balstilimab治疗晚期/转移性STS患者的单臂、开放标签II期试验

A single-arm, open-label phase 2 trial of doxorubicin plus zalifrelimab, a CTLA-4 inhibitor, with balstilimab, a PD-1 inhibitor, in patients with advanced/metastatic soft tissue sarcomas.

讲者: Breelyn A. Wilky, MD | University of Colorado Anschutz Medical Campus


摘要号:11502

ImmunoSarc2:多柔比星+达卡巴嗪+纳武利尤单抗一线治疗晚期平滑肌肉瘤,西班牙肉瘤小组(GEIS)Ib期试验

ImmunoSarc2: A Spanish Sarcoma Group (GEIS) phase Ib trial of doxorubicin and dacarbazine plus nivolumab in first line treatment of advanced leiomyosarcoma.

讲者: Javier Martin Broto, MD, PhD | Medical Oncology Department, Fundacion Jimenez Diaz University Hospital, Madrid, Spain, Institute of Biomedicine of Seville, University of Seville


摘要号:11503

Cabozantinib+纳武利尤单抗用于既往接受过紫杉类药物治疗的晚期血管肉瘤(AS)患者的多中心II期研究(Alliance A091902)

A multicenter phase II study of cabozantinib + nivolumab for patients (pts) with advanced angiosarcoma (AS) previously treated with a taxane (Alliance A091902).

讲者: Juneko E. Grilley-Olson, MD | Duke Cancer Institute, Duke University


摘要号:LBA11504

Cabozantinib联合PD-1和CTLA-4抑制剂对比Cabozantinib治疗转移性STS的II期随机试验

Randomized phase II trial of cabozantinib combined with PD-1 and CTLA-4 inhibition versus cabozantinib in metastatic soft tissue sarcoma.

讲者: Brian Andrew Van Tine, MD | Washington University Siteman Cancer Center


摘要号:11505

Cabozantinib联合替莫唑胺治疗不可切除/转移性平滑肌肉瘤和其他STS患者的II期研究

A phase II study of cabozantinib and temozolomide in patients with unresectable or metastatic leiomyosarcoma and other soft tissue sarcomas.

讲者: Mark Agulnik, MD | City of Hope Comprehensive Cancer Center


摘要号:11506

新辅助治疗高危STS的III期随机试验(ISG-STS 1001):同步放化疗的可行性和抗肿瘤活性

A phase III randomized trial of neo-adjuvant chemotherapy in high-risk soft tissue sarcoma (ISG-STS 1001): Feasibility and activity of concurrent chemotherapy and radiation therapy.

讲者: Elena Palassini, MD | Fondazione IRCCS Istituto Nazionale dei Tumori


摘要号:11507

Lurbinectedin(LURBI)+多柔比星(DOX)治疗STS和平滑肌肉瘤(LMS)的疗效:Ib/II期试验

Efficacy of combination lurbinectedin (LURBI) + doxorubicin (DOX) from the phase 1B soft-tissue sarcoma (STS) lead-in to a randomized phase 2 trial in leiomyosarcoma (LMS).

讲者: Gregory Michael Cote, MD | MGH Cancer Center


摘要号:11508

TTI-621联合多柔比星治疗不可切除/转移性高级别LMS患者的安全性和临床活性:来自低剂量扩展队列的结果

Safety and clinical activity of TTI-621 in combination with doxorubicin in patients with unresectable or metastatic high-grade leiomyosarcoma: Results from the low-dose expansion cohort.

讲者: Sujana Movva, MD | Memorial Sloan Kettering Cancer Center


临床科学研讨会

(Clinical Science Symposium)

摘要号:11509

应用循环肿瘤DNA(ctDNA)检测局部STS的MRD

Molecular residual disease (MRD) detection using bespoke circulating tumor DNA (ctDNA) assays in localized soft tissue sarcoma (STS).

讲者: Abdulazeez Salawu, PhD, MBBS, MSc, MRCP | Princess Margaret Cancer Centre, University Health Network


摘要号:11510

tumor-informed MRD检测在肉瘤中的临床价值

The clinical value of tumor-informed minimal residual disease detection in sarcoma

讲者: 尹军强教授 | 中山大学附属第一医院骨肿瘤科


摘要号:11511

高危STS经新辅助化疗(ChT)后的组织病理学反应(HR):ISG-STS-1001试验分析

Histopathological response (HR) after neoadjuvant chemotherapy (ChT) for high-risk soft tissue sarcomas (STS): A planned analysis of the ISG-STS-1001 trial.

讲者: Sandro Pasquali, MD, PhD | Molecular Pharmacology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano


摘要号:11512

基于影像的深度学习模型预测可切除高级别STS患者对新辅助化疗的组织学反应:一项多中心研究

Deep learning with whole slides images to predict histological response to neoadjuvant chemotherapy in patients with resectable high grade soft-tissue sarcomas: A multicenter study.

讲者: Antoine Italiano, MD | Early Phase Trials and Sarcoma Units, Institut Bergonié


壁报讨论专场(Poster Discussion Session)

摘要号:11513 | Poster Bd #447

妊娠对硬纤维瘤病女性的影响:一项国际回顾性观察性研究

Impact of pregnancy in women with desmoid fibromatosis: An international retrospective observational study.

讲者: Marco Fiore, MD, FACS | Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori


摘要号:11514 | Poster Bd #448

DeFi试验中肿瘤体积和T2高信号变化:nirogacestat治疗硬纤维瘤患者的III期随机对照试验

Tumor volume and T2 hyperintensity changes from DeFi: A phase 3, randomized, controlled trial of nirogacestat in patients with desmoid tumors.

讲者: Thierry Alcindor, MD, MSc | McGill University Health Center


摘要号:11515 | Poster Bd #449

AL102治疗硬纤维瘤(DT)的RINGSIDE II/III期试验结果

RINGSIDE phase 2/3 trial of AL102 for treatment of desmoid tumors (DT): Phase 2 results.

讲者: Mrinal M. Gounder, MD | Memorial Sloan Kettering Cancer Center


摘要号:11516 | Poster Bd #450

CTLA-4和PD-1抑制剂双免治疗罕见肿瘤(DART)的II期篮子试验:DT(SWOG S1609,队列27)

A phase II basket trial of dual anti–CTLA-4 and anti–PD-1 blockade in rare tumors (DART) SWOG S1609: The desmoid tumors (cohort 27).

讲者: Young Kwang Chae, MD, MBA | Northwestern University


摘要号:11517 | Poster Bd #451

仑伐替尼+帕博利珠单抗治疗晚期肉瘤患者的探索性研究

A pilot study of lenvatinib plus pembrolizumab in patients with advanced sarcoma.

讲者: Sujana Movva, MD | Memorial Sloan Kettering Cancer Center


摘要号:11518 | Poster Bd #452

Retifanlimab(R)联合吉西他滨和多西他赛(GD)一线治疗晚期STS患者:II期试验中期结果

Interim results of a phase II trial of first line retifanlimab (R) plus gemcitabine and docetaxel (GD) in patients (pts) with advanced soft tissue sarcoma (STS).

讲者: Evan Rosenbaum, MD | Memorial Sloan Kettering Cancer Center


摘要号:11519 | Poster Bd #453

SARC037:1小时输注trabectedin联合低剂量伊立替康治疗复发/难治性尤文肉瘤(ES)的I期研究结果

SARC037: Results of phase I study of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in relapsed/refractory Ewing sarcoma (ES).

讲者: Patrick Grohar | Children's Hospital of Philadelphia


摘要号:11520 | Poster Bd #454

SELISARC:西班牙肉瘤小组(GEIS)在特定肉瘤亚型中进行的selinexor联合吉西他滨的I/II期试验——I期部分的结果

SELISARC: A Spanish Sarcoma Group (GEIS) phase I/II trial of selinexor plus gemcitabine in selected sarcoma subtypes—Results of the phase I part.

讲者: Javier Martin Broto, MD, PhD | Fundacion Jimenez Diaz University Hospital and Health Research Institute-Fundación Jiménez Díaz University Hospital, Autonomous University of Madrid (IIS-FJD, UAM)


摘要号:11521 | Poster Bd #455

NAB-S联合pazopanib治疗晚期STS的I期临床研究

A phase I study of nanoparticle albumin-bound sirolimus (NAB-S) combined with pazopanib (PAZO) in patients with advanced soft tissue sarcoma (STS).

讲者: Lee D. Cranmer, MD, PhD | University of Washington, Fred Hutchinson Cancer Center


(本文依照报告日期和出场排序整理,如有错误或遗漏,敬请留言指正。)


参考文献

https://meetings.asco.org/meetings/2023-asco-annual-meeting/299/program-guide/search?q=Sarcoma

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评论
2023年05月15日
潘雪峰
中国人民解放军联勤保障部队第九八九医院 | 肿瘤科
好好学习,天天向上
2023年05月10日
王水
黑山县第一人民医院 | 外科
前沿速递一文纵览肉瘤重磅
2023年05月09日
陈华福
厦门大学附属东南医院(解放军第175医院) | 外科
2023 ASCO】前沿速递!一文纵览