2023年第59届美国临床肿瘤学会(ASCO)年会将于美国芝加哥当地时间6月2~6日举行,一年一度的学术盛宴将启。ASCO官网已公布会议日程和摘要题目。【肿瘤资讯】特别整理口头报告专场(Oral Abstract Session)、临床科学研讨会(Clinical Science Symposium),以及壁报讨论专场(Poster Discussion Session)的肉瘤研究,揭秘前沿进展。
口头报告专场(Oral Abstract Session)
摘要号:11500
纳武利尤单抗联合trabectedin用于经治晚期软组织肉瘤(STS)患者的疗效和安全性:德国跨学科肉瘤小组(GISG-15, NitraSarc)的II期试验结果
Efficacy and safety of nivolumab and trabectedin in pretreated patients with advanced soft tissue sarcomas (STS): Results of a phase II trial of the German Interdisciplinary Sarcoma Group (GISG-15, NitraSarc).
讲者: Peter Reichardt, MD, PhD | HELIOS Klinikum Berlin-Buch, Klinik für Interdisziplinäre Onkologie, Sarkomzentrum Berlin-Brandenburg
摘要号:11501
多柔比星+CTLA-4抑制剂Zalifrelimab+PD-1抑制剂balstilimab治疗晚期/转移性STS患者的单臂、开放标签II期试验
A single-arm, open-label phase 2 trial of doxorubicin plus zalifrelimab, a CTLA-4 inhibitor, with balstilimab, a PD-1 inhibitor, in patients with advanced/metastatic soft tissue sarcomas.
讲者: Breelyn A. Wilky, MD | University of Colorado Anschutz Medical Campus
摘要号:11502
ImmunoSarc2:多柔比星+达卡巴嗪+纳武利尤单抗一线治疗晚期平滑肌肉瘤,西班牙肉瘤小组(GEIS)Ib期试验
ImmunoSarc2: A Spanish Sarcoma Group (GEIS) phase Ib trial of doxorubicin and dacarbazine plus nivolumab in first line treatment of advanced leiomyosarcoma.
讲者: Javier Martin Broto, MD, PhD | Medical Oncology Department, Fundacion Jimenez Diaz University Hospital, Madrid, Spain, Institute of Biomedicine of Seville, University of Seville
摘要号:11503
Cabozantinib+纳武利尤单抗用于既往接受过紫杉类药物治疗的晚期血管肉瘤(AS)患者的多中心II期研究(Alliance A091902)
A multicenter phase II study of cabozantinib + nivolumab for patients (pts) with advanced angiosarcoma (AS) previously treated with a taxane (Alliance A091902).
讲者: Juneko E. Grilley-Olson, MD | Duke Cancer Institute, Duke University
摘要号:LBA11504
Cabozantinib联合PD-1和CTLA-4抑制剂对比Cabozantinib治疗转移性STS的II期随机试验
Randomized phase II trial of cabozantinib combined with PD-1 and CTLA-4 inhibition versus cabozantinib in metastatic soft tissue sarcoma.
讲者: Brian Andrew Van Tine, MD | Washington University Siteman Cancer Center
摘要号:11505
Cabozantinib联合替莫唑胺治疗不可切除/转移性平滑肌肉瘤和其他STS患者的II期研究
A phase II study of cabozantinib and temozolomide in patients with unresectable or metastatic leiomyosarcoma and other soft tissue sarcomas.
讲者: Mark Agulnik, MD | City of Hope Comprehensive Cancer Center
摘要号:11506
新辅助治疗高危STS的III期随机试验(ISG-STS 1001):同步放化疗的可行性和抗肿瘤活性
A phase III randomized trial of neo-adjuvant chemotherapy in high-risk soft tissue sarcoma (ISG-STS 1001): Feasibility and activity of concurrent chemotherapy and radiation therapy.
讲者: Elena Palassini, MD | Fondazione IRCCS Istituto Nazionale dei Tumori
摘要号:11507
Lurbinectedin(LURBI)+多柔比星(DOX)治疗STS和平滑肌肉瘤(LMS)的疗效:Ib/II期试验
Efficacy of combination lurbinectedin (LURBI) + doxorubicin (DOX) from the phase 1B soft-tissue sarcoma (STS) lead-in to a randomized phase 2 trial in leiomyosarcoma (LMS).
讲者: Gregory Michael Cote, MD | MGH Cancer Center
摘要号:11508
TTI-621联合多柔比星治疗不可切除/转移性高级别LMS患者的安全性和临床活性:来自低剂量扩展队列的结果
Safety and clinical activity of TTI-621 in combination with doxorubicin in patients with unresectable or metastatic high-grade leiomyosarcoma: Results from the low-dose expansion cohort.
讲者: Sujana Movva, MD | Memorial Sloan Kettering Cancer Center
临床科学研讨会
(Clinical Science Symposium)
摘要号:11509
应用循环肿瘤DNA(ctDNA)检测局部STS的MRD
Molecular residual disease (MRD) detection using bespoke circulating tumor DNA (ctDNA) assays in localized soft tissue sarcoma (STS).
讲者: Abdulazeez Salawu, PhD, MBBS, MSc, MRCP | Princess Margaret Cancer Centre, University Health Network
摘要号:11510
tumor-informed MRD检测在肉瘤中的临床价值
The clinical value of tumor-informed minimal residual disease detection in sarcoma
讲者: 尹军强教授 | 中山大学附属第一医院骨肿瘤科
摘要号:11511
高危STS经新辅助化疗(ChT)后的组织病理学反应(HR):ISG-STS-1001试验分析
Histopathological response (HR) after neoadjuvant chemotherapy (ChT) for high-risk soft tissue sarcomas (STS): A planned analysis of the ISG-STS-1001 trial.
讲者: Sandro Pasquali, MD, PhD | Molecular Pharmacology, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano
摘要号:11512
基于影像的深度学习模型预测可切除高级别STS患者对新辅助化疗的组织学反应:一项多中心研究
Deep learning with whole slides images to predict histological response to neoadjuvant chemotherapy in patients with resectable high grade soft-tissue sarcomas: A multicenter study.
讲者: Antoine Italiano, MD | Early Phase Trials and Sarcoma Units, Institut Bergonié
壁报讨论专场(Poster Discussion Session)
摘要号:11513 | Poster Bd #447
妊娠对硬纤维瘤病女性的影响:一项国际回顾性观察性研究
Impact of pregnancy in women with desmoid fibromatosis: An international retrospective observational study.
讲者: Marco Fiore, MD, FACS | Sarcoma Service, Fondazione IRCCS Istituto Nazionale dei Tumori
摘要号:11514 | Poster Bd #448
DeFi试验中肿瘤体积和T2高信号变化:nirogacestat治疗硬纤维瘤患者的III期随机对照试验
Tumor volume and T2 hyperintensity changes from DeFi: A phase 3, randomized, controlled trial of nirogacestat in patients with desmoid tumors.
讲者: Thierry Alcindor, MD, MSc | McGill University Health Center
摘要号:11515 | Poster Bd #449
AL102治疗硬纤维瘤(DT)的RINGSIDE II/III期试验结果
RINGSIDE phase 2/3 trial of AL102 for treatment of desmoid tumors (DT): Phase 2 results.
讲者: Mrinal M. Gounder, MD | Memorial Sloan Kettering Cancer Center
摘要号:11516 | Poster Bd #450
CTLA-4和PD-1抑制剂双免治疗罕见肿瘤(DART)的II期篮子试验:DT(SWOG S1609,队列27)
A phase II basket trial of dual anti–CTLA-4 and anti–PD-1 blockade in rare tumors (DART) SWOG S1609: The desmoid tumors (cohort 27).
讲者: Young Kwang Chae, MD, MBA | Northwestern University
摘要号:11517 | Poster Bd #451
仑伐替尼+帕博利珠单抗治疗晚期肉瘤患者的探索性研究
A pilot study of lenvatinib plus pembrolizumab in patients with advanced sarcoma.
讲者: Sujana Movva, MD | Memorial Sloan Kettering Cancer Center
摘要号:11518 | Poster Bd #452
Retifanlimab(R)联合吉西他滨和多西他赛(GD)一线治疗晚期STS患者:II期试验中期结果
Interim results of a phase II trial of first line retifanlimab (R) plus gemcitabine and docetaxel (GD) in patients (pts) with advanced soft tissue sarcoma (STS).
讲者: Evan Rosenbaum, MD | Memorial Sloan Kettering Cancer Center
摘要号:11519 | Poster Bd #453
SARC037:1小时输注trabectedin联合低剂量伊立替康治疗复发/难治性尤文肉瘤(ES)的I期研究结果
SARC037: Results of phase I study of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in relapsed/refractory Ewing sarcoma (ES).
讲者: Patrick Grohar | Children's Hospital of Philadelphia
摘要号:11520 | Poster Bd #454
SELISARC:西班牙肉瘤小组(GEIS)在特定肉瘤亚型中进行的selinexor联合吉西他滨的I/II期试验——I期部分的结果
SELISARC: A Spanish Sarcoma Group (GEIS) phase I/II trial of selinexor plus gemcitabine in selected sarcoma subtypes—Results of the phase I part.
讲者: Javier Martin Broto, MD, PhD | Fundacion Jimenez Diaz University Hospital and Health Research Institute-Fundación Jiménez Díaz University Hospital, Autonomous University of Madrid (IIS-FJD, UAM)
摘要号:11521 | Poster Bd #455
NAB-S联合pazopanib治疗晚期STS的I期临床研究
A phase I study of nanoparticle albumin-bound sirolimus (NAB-S) combined with pazopanib (PAZO) in patients with advanced soft tissue sarcoma (STS).
讲者: Lee D. Cranmer, MD, PhD | University of Washington, Fred Hutchinson Cancer Center
(本文依照报告日期和出场排序整理,如有错误或遗漏,敬请留言指正。)
https://meetings.asco.org/meetings/2023-asco-annual-meeting/299/program-guide/search?q=Sarcoma
排版编辑:肿瘤资讯-Marie