当地时间2024年3月13日~15日，由欧洲神经内分泌肿瘤学会（ENETS）主办的第21届ENETS年会将在奥地利维也纳拉开序幕。今年，ENETS共收到317篇摘要，涵盖基础科学/转化（basic science/translational）、临床科学（clinical scientific）、病例报告（case reports）、进行中试验（trial-in-concept/trials-in-progress）和护理等多个方面。评审委员会已经选出30余篇摘要进行口头报告，并有12篇摘要将在壁报展示区展示。此次年会将为与会者带来最新的研究成果，为神经内分泌肿瘤领域的进步注入新的活力。【肿瘤资讯】特别整理了口头报告标题，以飨诸君。
入选口头报告的研究
A.基础科学-遗传学、表观遗传学、微生物学、组学
(A03) Backman, S. et al. The evolutionary history of metastatic pancreatic neuroendocrine tumors reveals a therapy driven routeto high-grade transformation
中文标题：转移性胰腺神经内分泌肿瘤的进化历史揭示了治疗驱动的高级别转化途径
(A05) Chouchane, A. et al. Transcriptomic analysis of PanNET tumor progression from microtumor to metastasis in MEN1 patients
中文标题：MEN1相关PanNET患者的肿瘤从微小肿瘤到转移的转录组学分析
(A15) Mäkinen, N. et al. Characterising the tumor microenvironment of multifocal small intestinal NETs
中文标题：多灶性小肠NETs的肿瘤微环境特征
(A20) Pedraza-Arévalo, S. et al. Specific spliceosomic landscapes reveal a possible link between RNA processing and panNETs behaviour
中文标题：特定的剪接体图谱揭示了RNA加工和panNETs行为之间的可能联系
(A22) Simbolo, M. et al. Integrative molecular analysis of lung neuroendocrine neoplasms with different Ki-67 indices identifies a molecular transition group between low- and high-grade neoplasms
中文标题：对不同Ki-67指数的肺神经内分泌肿瘤进行整合分子分析，确定了低级别和高级别肿瘤之间的分子转换组
(A26) Trevisani, E. et al. DNA damage repair genes alterations in pancreatic neuroendocrine tumor treated with Temozolomide
中文标题：替莫唑胺治疗胰腺神经内分泌肿瘤后DNA损伤修复基因的改变
(A27) Webster, A. et al. Epigenetic prediction of aging and metabolic traits provides insight into tumor biology in multi-focal ilealneuroendocrine tumors
中文标题：多灶性回肠神经内分泌肿瘤的表观遗传学预测对肿瘤生物学有重要意义
B.基础科学-体外模型、肿瘤生长、CTCs
(B01) Bräutigam, K. et al. Decoding and targeting of metabolic heterogeneity in pancreatic neuroendocrine tumors (PanNETs):MCT1 and MCT4 in the crosshair for precision therapy
中文标题：胰腺神经内分泌肿瘤（PanNETs）代谢异质性的解码和靶向：精准治疗的十字准星MCT1和MCT4
(B02) Castanho Martins, M. et al. Mesenteric fibrosis in small intestinal neuroendocrine tumors (SI-NETs): Pathogenesis andtherapeutic targets
中文标题：小肠神经内分泌肿瘤（SI-NETs）的肠系膜纤维化：发病机制和治疗靶点
(B03) Chaoul, N. et al. Ex vivo expansion of TILs from panNET liver metastasis: In search of novel adoptive transfer strategies forthe treatment of NETs
中文标题：体外扩增panNET肝转移瘤TILs：寻找治疗NETs的新型过继转移策略
(B05) Kulathunga, N. et al. Establishment of novel patient-derived preclinical models for neuroendocrine tumors
中文标题：神经内分泌肿瘤患者来源的新型临床前模型的建立
D. 流行病学/自然史/预后-登记处、全国和区域调查
(D17) Clement, D. et al. The global leadership into malnutrition criteria reveals a high percentage of malnutrition which negatively influences overall survival in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs) treated with somatostatin analogues
中文标题：在使用生长抑素类似物治疗的胃肠胰神经内分泌肿瘤（GEP-NETs）患者中，营养不良的比例高，这对患者的总生存期产生了影响
(D50) Penugonda, M. et al. Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH): An international case series
中文标题：弥漫性特发性肺神经内分泌细胞增生症（DIPNECH）：国际病例系列
E. 病理学-分级、分期
(E03) Andreasi, V. et al. Prognostic significance of nodal micrometastases in patients with non-functioning pancreaticneuroendocrine tumors (NF-PanNETs) – A survival analysis from a prospective observational study
中文标题：无功能性胰腺神经内分泌肿瘤（NF-PanNETs）患者淋巴结微转移的预后意义——一项前瞻性、观察研究的生存分析
(E09) Kasajima, A. et al. New insights into the progression of NET G3 with a focus of NETs with NEC-like transformation
中文标题：对G3 NET 进展的新见解，重点聚焦具有NEC样转化的NETs
F. 生物标志物-临床应用
(F03) Catoya, J. et al. MAPK and mTOR pathway activation is associated with chemotherapy resistance and a poor prognosis in G3 advanced NENs
中文标题：在G3晚期神经内分泌肿瘤中，MAPK和mTOR通路的激活与化疗耐药、不良预后相关
(F04) Farinea, G. et al. Precision medicine in advanced NENs: Molecular profiling and target actionability real world data
中文标题：晚期NENs的精准医学：分子特征分析和真实世界数据
(F07) Jannin, A. et al. Metabolite biomarker discovery for pancreatic neuroendocrine tumors using metabolomic approach
中文标题：利用代谢组学方法发现胰腺神经内分泌肿瘤的代谢物生物标志物
(F23) Sponheim, J. et al. 5-Hydroxymethylcytosine profiling of plasma-derived circulating free DNA in patients with pancreaticneuroendocrine tumors treated with [177Lu]Lu-DOTA-TATE
中文标题：[177Lu]Lu-DOTA-TATE治疗的胰腺神经内分泌肿瘤患者血浆游离DNA的5 -羟甲基胞嘧啶谱分析
H.核医学-影像和治疗（PRRT）
(H05) Chan, D. et al. Metabolic tumor volume (MTV) as a biomarker in patients with gastroenteropancreatic neuroendocrineneoplasms (GEPNENs): A multi-center study
中文标题：代谢性肿瘤体积（MTV）作为胃肠胰神经内分泌肿瘤（GEPNENs）患者的生物标志物：一项多中心研究
(H06) de Herder, W. et al. [177Lu]Lu-DOTA-TATE in newly diagnosed patients with advanced grade 2 and grade 3, welldifferentiated gastroenteropancreatic neuroendocrine tumors: Primary analysis of the phase 3 randomised NETTER-2 study
中文标题：[177Lu]Lu-DOTA-TATE治疗初诊晚期2级和3级高分化胃肠胰神经内分泌肿瘤：NETTER-2 3期随机研究的初步分析
(H08) Leupe, H. et al. PET/CT imaging of the somatostatin receptor with [18F]AlF-NOTA-octreotide PET/CT: Analysis of impact ontumor staging and therapeutic management
中文标题：[18F]AlF-NOTA-octreotide PET/CT ：对肿瘤分期和治疗管理的影响分析
(H16) Oziel-Taieb, S. et al. Predictive factors of persistent thrombocytopenia after 177Lu-DOTATATE in patients with neuroendocrine tumors
中文标题：177Lu-DOTATATE治疗神经内分泌肿瘤后持续血小板减少的预测因素
I. 治疗-所有类型的系统抗肿瘤治疗（SACT）
(I03) Capdevila, J. et al. Updated data from a phase I trial of the DLL3/CD3 IgG-like T-cell engager BI 764532 in patients (pts) withDLL3-positive (+) tumors: Focus on extrapulmonary neuroendocrine carcinomas (epNECs)
中文标题：BI 764532在DLL3阳性肿瘤患者中的I期试验的最新数据：聚焦肺外神经内分泌癌（epNECs）
(I08) Dasari, A. et al. A phase II study of Lenvatinib and Everolimus in advanced well-differentiated extrapancreatic neuroendocrine tumors
中文标题：仑伐替尼和依维莫司治疗晚期高分化胰腺外神经内分泌肿瘤的II期临床研究
(I09) de Mestier, L. et al. Temozolomide treatment induces an MMR-dependent hypermutator phenotype in well-differentiated pancreatic neuroendocrine tumors
中文标题：替莫唑胺治疗在分化良好的胰腺神经内分泌肿瘤中诱导出MMR依赖的超突变体表型
(I21) Molina-Cerrillo, J. et al. Responses to Cabozantinib plus Atezolizumab in a wide population of advanced and progressive neuroendocrine neoplasms (NENs): A prospective multi-cohort basket phase II Trial (CABATEN / GETNE-T1914)
中文标题：Cabozantinib联合阿替利珠单抗治疗晚期和进展期神经内分泌肿瘤(NENs)的人群应答：一项前瞻性、多队列篮式II期试验(CABATEN/GETNE-T1914)
(I24) Sorbye, H. et al. Nordic NEC 2: Characteristics and treatment outcome in a prospective cohort of 698 patients with high-grade digestive neuroendocrine neoplasms (NET G3 and NEC)
中文标题：前瞻性队列研究（Nordic NEC 2）：698例高级别消化道神经内分泌肿瘤（NET G3和NEC）患者的特征和治疗结果
J. 外科主题
(J05) Bertani, E. et al. Radio-guided surgery with a new generation β-probe for radiolabelled somatostatin analogue, in patientswith small intestinal neuroendocrine tumors – A Phase II surgical trial
中文标题：在小肠神经内分泌肿瘤患者中使用新一代β探针进行放射标记生长抑素类似物的放射引导手术：一项II 期手术试验
(J12) Manoharan, J. et al. Evaluation of circulating extracellular vesicles as suitable prognostic markers in MEN1-associated nonfunctioning pancreatic neuroendocrine neoplasia
中文标题：评估循环细胞外囊泡作为MEN1相关无功能性胰腺神经内分泌肿瘤合适的预后标志物
(J13) Nießen, A. et al. Portal vein resection in pancreatic neuroendocrine neoplasms
中文标题：胰腺神经内分泌肿瘤中门静脉切除术的应用
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