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2025 ESMO Asia | 肺癌领域重磅研究一文速览

11月05日
来源:ESMO Asia Congress 2025官网

2025年欧洲肿瘤内科学会亚洲年会(ESMO Asia Congress 2025)将于12月5日—12月7日在新加坡举行。目前,官网已公布摘要标题及作者信息。
【肿瘤资讯】特此整理了肺癌领域的口头报告摘要标题,以飨读者。

Mini Oral session 1: Thoracic malignancies

摘要号:LBA14

英文标题:First-in-Human Phase 1 Study of GTA182, a Novel MTA-Cooperative PRMT5 Inhibitor, in Patients with MTAP-Deleted Advanced Non-Small Cell Lung Cancer

中文标题:GTA182(一种新型MTA协同PRMT5抑制剂)治疗MTAP缺失晚期非小细胞肺癌患者的首次人体I期研究

讲者:陆舜(中国,上海)

摘要号:928MO

英文标题:ARTEMIS-001: A Phase 1 Study of HS-20093 (GSK5764227) in Patients With Non-Small Cell Lung Cancer (NSCLC)

中文标题:ARTEMIS-001:HS-20093 (GSK5764227) 治疗非小细胞肺癌 (NSCLC) 患者的一项I期研究

讲者:段建春(中国,北京)

摘要号:978MO

英文标题:Sintilimab Plus Platinum-Based Chemotherapy With vs Without Autologous CIK Cell Therapy in Metastatic NSCLC: A Multicenter Randomized Study

中文标题:信迪利单抗联合铂类化疗对比联合或不联合自体CIK细胞治疗用于转移性NSCLC的多中心随机研究

讲者:黄鼎智(中国,天津)

摘要号:929MO

英文标题: Becotatug (JMT101, Beco) Combined with Docetaxel (Albumin-Bound, HB1801) for the Treatment of Patients (pts) with Locally Advanced Squamous Cell Non-Small Cell Lung Cancer (sqNSCLC) -A randomized control phase II study (BATTLE study)

中文标题:Becotatug (JMT101, Beco) 联合多西他赛(白蛋白结合型,HB1801)治疗局部晚期鳞状非小细胞肺癌 (sqNSCLC) 患者的随机对照II期研究 (BATTLE研究)

讲者:张力(中国,广州)

摘要号:979MO

英文标题:Plinabulin/Docetaxel vs. Docetaxel in 2L/3L EGFRwt NSCLC after Platinum Regimens (DUBLIN-3): Asian Subgroup Analysis

中文标题:普那布林/多西他赛对比多西他赛用于铂类方案治疗后的二/三线EGFR野生型NSCLC患者 (DUBLIN-3):亚洲亚组分析

讲者:韩宝惠(中国,上海)

摘要号:LBA15

英文标题:Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant EGFR and HER2 Inhibitor, in Previously Treated NSCLC with EGFR Atypical Mutations: Randomized Dose Optimization and CNS Activity

中文标题:Enozertinib (ORIC-114)(一种高度选择性、脑部渗透性EGFR和HER2抑制剂)在先前接受治疗的具有EGFR非典型突变NSCLC患者中的应用:随机剂量优化和CNS活性

讲者:Min Hee Hong (Seoul, KR)

摘要号:937MO

英文标题:Phase I/II SOHO-01 study of sevabertinib (BAY 2927088) in HER2-mutant non-small cell lung cancer (NSCLC): safety and efficacy in Asian patients

中文标题:Sevabertinib (BAY 2927088) 治疗HER2突变型非小细胞肺癌 (NSCLC) 的 I/II 期 SOHO-01 研究:亚洲患者的安全性和疗效

讲者:Daniel Shao Weng Tan (Singapore, SG)

摘要号:974MO

英文标题:Efficacy of zipalertinib in Asian patients with EGFR exon 20 insertion mutated (Ex20ins) advanced non-small cell lung cancer (NSCLC)

中文标题:Zipalertinib治疗具有EGFR外显子20插入突变 (Ex20ins) 的晚期非小细胞肺癌 (NSCLC) 亚洲患者的疗效

讲者:Ross A. Soo (Singapore, SG)

摘要号:975MO

英文标题:Zongertinib in Asian patients with previously treated advanced HER2-mutant NSCLC

中文标题:宗艾替尼治疗先前接受过治疗的晚期HER2突变型NSCLC亚洲患者

讲者:吴一龙(中国,广州)

Proffered Paper session: Thoracic malignancies

摘要号:LBA10

英文标题:Crizotinib plus Chemotherapy versus Crizotinib alone in Advanced Non-Small Cell Lung Cancer with ALK rearrangement.

中文标题:克唑替尼联合化疗对比克唑替尼单药治疗ALK重排的晚期非小细胞肺癌

讲者:Nandini S. Menon (Mumbai, IN)

摘要号:LBA11

英文标题:A Phase II Clinical Study of Dose Optimization for ZG006 (Alveltamig) in Patients with Advanced Small Cell Lung Cancer Who Have Received at Least Two Prior Lines of Therapy (ZG006-002)

中文标题:ZG006 (Alveltamig) 在既往接受过至少两线治疗的晚期小细胞肺癌患者中进行剂量优化的 II 期临床研究 (ZG006-002)

讲者:李子明(中国,上海)

摘要号:972O

英文标题:Overall Survival for Amivantamab Plus Lazertinib vs Osimertinib in Asian Participants With First-line EGFR-mutant Advanced NSCLC: MARIPOSA Subgroup Analysis

中文标题:埃万妥单抗联合兰泽替尼对比奥希替尼一线治疗EGFR突变晚期NSCLC亚洲受试者的总生存期:MARIPOSA 亚组分析

讲者:Hidetoshi Hayashi (Osaka, JP)

摘要号:LBA12

英文标题:Safety Profile and Anti-Tumor Efficacy of VRN110755, a highly selective, brain penetrant EGFR inhibitor for Patients with EGFR-driven non-small Cell Lung Cancer

中文标题:VRN110755(一种高度选择性、脑部渗透性EGFR抑制剂)治疗EGFR驱动型非小细胞肺癌患者的安全性概况和抗肿瘤疗效

讲者:Myung-Ju Ahn (Seoul, KR)

摘要号:LBA13

英文标题:Enozertinib (ORIC-114), a Highly Selective, Brain Penetrant EGFR and HER2 Inhibitor, in EGFR Exon 20 Mutant NSCLC: Randomized Dose Optimization and CNS Activity

中文标题:Enozertinib (ORIC-114)(一种高度选择性、脑部渗透性EGFR和HER2抑制剂)治疗EGFR外显子20突变型NSCLC:随机剂量优化和CNS活性

讲者:Thomas John (Melbourne, AU)

Mini oral session 2: Thoracic malignancies

摘要号:976MO

英文标题:Vebreltinib in MET amplification-driven advanced non-small-cell lung cancer (NSCLC): results from phase 2 KUNPENG study

中文标题:Vebreltinib治疗MET扩增驱动的晚期非小细胞肺癌 (NSCLC):II 期KUNPENG研究结果

讲者:吴一龙(中国,广州)

摘要号:977MO

英文标题:Safety and Efficacy of Elironrasib, a RAS(ON) G12C-Selective Inhibitor, in Previously Treated Patients with KRAS G12C NSCLC

中文标题:RAS(ON) G12C选择性抑制剂Elironrasib在既往接受过治疗的KRAS G12C NSCLC患者中的安全性和疗效

讲者:Daniel Shao Weng Tan (Singapore, SG)

摘要号:902MO 

英文标题:Preliminary data on Genome-wide cfDNA fragmentation features from the U.S.-based Female Asian Nonsmoker Screening Study (FANSS)

中文标题:来自美国女性亚裔非吸烟者筛查研究 (FANSS) 的全基因组cfDNA片段化特征初步数据

讲者:Elaine Shum (New York, US)

摘要号:991MO

英文标题:Prophylactic Management of Dermatologic Adverse Events with Amivantamab + Lazertinib Treatment in 1L EGFR-mutated NSCLC: COCOON Asian Subset Analysis

中文标题:埃万妥单抗联合兰泽替尼一线治疗EGFR突变NSCLC的皮肤学不良事件的预防性管理:COCOON亚洲亚组分析

讲者:Pei-Jye Voon (Kuching, MY)

摘要号:LBA8

英文标题:Driver Gene–Specific ctDNA Monitoring as a Cost-Effective MRD Strategy in Resectable Stage III Driver-Mutant NSCLC: First Analysis of a Multicenter, Prospective Study (NCT06443684)

中文标题:驱动基因特异性ctDNA监测作为可切除III期驱动基因突变型NSCLC的成本效益MRD策略:一项多中心、前瞻性研究 (NCT06443684) 的首次分析

讲者:李子明(中国,上海)

摘要号:927MO

英文标题:Osimertinib (osi) before and after chemoradiotherapy (CRT) in patients (pts) with unresectable (UR) stage III EGFRm NSCLC: Phase 2 NEOLA study interim analysis (IA)

中文标题:不可切除 (UR) III 期EGFR突变NSCLC患者在放化疗 (CRT) 前后使用奥希替尼 (osi):II 期NEOLA研究中期分析 (IA)

讲者:陈明(中国,广州)

摘要号:LBA9

英文标题:Perioperative pembrolizumab in early-stage non–small-cell lung cancer (NSCLC): 5-year follow-up from the KEYNOTE-671 global study and Asian subgroup

中文标题:帕博利珠单抗围手术期治疗早期非小细胞肺癌 (NSCLC):来自KEYNOTE-671全球研究和亚洲亚组的5年随访结果

讲者:Masahiro Tsuboi (Kashiwa, JP)

摘要号:903MO

英文标题:Neoadjuvant (neoadj) osimertinib (osi) ± chemotherapy (CT) vs CT alone in patients (pts) with resectable epidermal growth factor receptor-mutated (EGFRm) stage II–IIIB non-small cell lung cancer (NSCLC): patient-reported outcomes (PROs) from NeoADAURA

中文标题:可切除II–IIIB期表皮生长因子受体突变型 (EGFRm) 非小细胞肺癌 (NSCLC) 患者的新辅助 (neoadj) 奥希替尼 (osi) ± 化疗 (CT) 对比单纯 CT:来自NeoADAURA的患者报告结局 (PRO)

讲者:陈克能(中国,北京)

摘要号:980MO

英文标题:Lurbinectedin (lurbi) + atezolizumab (atezo) as first-line (1L) maintenance treatment (tx) in patients (pts) with extensive-stage small-cell lung cancer (ES-SCLC): IMforte Asia subgroup results

中文标题:芦比替定 (lurbi) + 阿替利珠单抗 (atezo) 作为广泛期小细胞肺癌 (ES-SCLC) 患者的一线 (1L) 维持治疗 (tx):IMforte亚洲亚组结果

讲者:Yaewon Yang (Cheongju, KR)

摘要号:930MO

英文标题:Ifinatamab deruxtecan (I-DXd) in extensive-stage (ES) small cell lung cancer (SCLC): Asian subgroup analysis from the Phase 2 IDeate-Lung01 study

中文标题:Ifinatamab deruxtecan (I-DXd) 治疗广泛期 (ES) 小细胞肺癌 (SCLC):来自II期IDeate-Lung01研究的亚洲亚组分析

讲者:Hidetoshi Hayashi (Osaka, JP)



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